2014 |
Tirapegui, C; Toro-Sazo, M A; Cassels, B K Synthesis of N-(Halogenated) Benzyl Analogs of Superpotent Serotonin Ligands Artículo de revista Journal of the Chilean Chemical Society, 59 (3), pp. 2625-2627, 2014, ISSN: 0717-9707. Resumen | Enlaces | BibTeX | Etiquetas: n-benzylphenylethylamine, n-benzyltryptamine, receptor, synthesis @article{RN191, title = {Synthesis of N-(Halogenated) Benzyl Analogs of Superpotent Serotonin Ligands}, author = { C. Tirapegui and M.A. Toro-Sazo and B.K. Cassels}, url = {/brokenurl#<Go to ISI>://WOS:000347833800022}, doi = {10.4067/S0717-97072014000300022}, issn = {0717-9707}, year = {2014}, date = {2014-01-01}, journal = {Journal of the Chilean Chemical Society}, volume = {59}, number = {3}, pages = {2625-2627}, abstract = {In the last four years a group of extremely potent designer drugs, the N-benzylated phenylethylamines known as the NBOMe series, has surfaced on the street and in the news media. Although data documenting their high affinity and preference for 5-HT2 serotonin receptors abound (5-HT2A receptor activation is generally associated with the action of the "classical" hallucinogens), relatively little is known about the molecular basis of their potency and selectivity. In the setting of a project aiming to evaluate the possible involvement of halogen bonds in the binding of monoaminergic ligands to their receptors, we have begun to synthesize halogenated derivatives of known N-benzylated compounds for their pharmacological study. Here we report the synthesis of new phenylethylamine and tryptamine derivatives incorporating bromine atoms in their N-benzyl moiety.}, keywords = {n-benzylphenylethylamine, n-benzyltryptamine, receptor, synthesis}, pubstate = {published}, tppubtype = {article} } In the last four years a group of extremely potent designer drugs, the N-benzylated phenylethylamines known as the NBOMe series, has surfaced on the street and in the news media. Although data documenting their high affinity and preference for 5-HT2 serotonin receptors abound (5-HT2A receptor activation is generally associated with the action of the "classical" hallucinogens), relatively little is known about the molecular basis of their potency and selectivity. In the setting of a project aiming to evaluate the possible involvement of halogen bonds in the binding of monoaminergic ligands to their receptors, we have begun to synthesize halogenated derivatives of known N-benzylated compounds for their pharmacological study. Here we report the synthesis of new phenylethylamine and tryptamine derivatives incorporating bromine atoms in their N-benzyl moiety. |
2014 |
Synthesis of N-(Halogenated) Benzyl Analogs of Superpotent Serotonin Ligands Artículo de revista Journal of the Chilean Chemical Society, 59 (3), pp. 2625-2627, 2014, ISSN: 0717-9707. |