Costantino, A R; Schneider, M G M; Galdamez, A; Ocampo, R A; Mandolesi, S D; Koll, L C The Synthesis of C-2 Symmetry Diesters of (3r,4r)-Ttfol through a Green and Stereoselective (2r,3r)-Taddol Rearrangement Artículo de revista Tetrahedron-Asymmetry, 26 (23), pp. 1341-1347, 2015, ISSN: 0957-4166. Resumen | Enlaces | BibTeX | Etiquetas: analogs, anhydrides carboxylic-acids, derivatives, esterification, esters, in-situ, inhibitors, integrase ligands, taddol @article{RN258,
title = {The Synthesis of C-2 Symmetry Diesters of (3r,4r)-Ttfol through a Green and Stereoselective (2r,3r)-Taddol Rearrangement},
author = { A.R. Costantino and M.G.M. Schneider and A. Galdamez and R.A. Ocampo and S.D. Mandolesi and L.C. Koll},
url = {/brokenurl#<Go to ISI>://WOS:000366070000005},
doi = {10.1016/j.tetasy.2015.10.014},
issn = {0957-4166},
year = {2015},
date = {2015-01-01},
journal = {Tetrahedron-Asymmetry},
volume = {26},
number = {23},
pages = {1341-1347},
publisher = {2015 Elsevier Ltd.},
abstract = {An efficient, green, and atom economic methodology for the stereoselective synthesis of C-2 symmetry (3R,4R)-TTFOL diester derivatives has been developed. The procedure occurs through a (2R,3R)-TADDOL dioxolane cleavage and rearrangement under mild conditions by its reaction with a carboxylic acid in the presence of TFAA/H3PO4 without the need for an inert atmosphere to give generally high yields.},
keywords = {analogs, anhydrides carboxylic-acids, derivatives, esterification, esters, in-situ, inhibitors, integrase ligands, taddol},
pubstate = {published},
tppubtype = {article}
}
An efficient, green, and atom economic methodology for the stereoselective synthesis of C-2 symmetry (3R,4R)-TTFOL diester derivatives has been developed. The procedure occurs through a (2R,3R)-TADDOL dioxolane cleavage and rearrangement under mild conditions by its reaction with a carboxylic acid in the presence of TFAA/H3PO4 without the need for an inert atmosphere to give generally high yields. |
