2011 |
Arrau, S; Delporte, C; Cartagena, C; Rodriguez-Diaz, M; González, P; Silva, X; Cassels, B K; Miranda, H F Antinociceptive Activity of Quillaja Saponaria Mol. Saponin Extract, Quillaic Acid and Derivatives in Mice Artículo de revista Journal of Ethnopharmacology, 133 (1), pp. 164-167, 2011, ISSN: 0378-8741. Resumen | Enlaces | BibTeX | Etiquetas: activity, analgesic assay, derivatives, drugs hot-plate models, pain, quillaic quillaja saponaria, tail-flick @article{RN4m, title = {Antinociceptive Activity of Quillaja Saponaria Mol. Saponin Extract, Quillaic Acid and Derivatives in Mice}, author = { S. Arrau and C. Delporte and C. Cartagena and M. Rodriguez-Diaz and P. Gonz\'{a}lez and X. Silva and B.K. Cassels and H.F. Miranda}, url = {/brokenurl#<Go to ISI>://WOS:000286854100023}, doi = {10.1016/j.jep.2010.09.016}, issn = {0378-8741}, year = {2011}, date = {2011-01-01}, journal = {Journal of Ethnopharmacology}, volume = {133}, number = {1}, pages = {164-167}, publisher = {2010 Elsevier Ireland Ltd.}, abstract = {Ethnopharmacological relevance: Quillaja saponaria bark contains a high percentage of triterpene saponins and has been used for centuries as a cleansing and analgesic agent in Chilean folk medicine., Aim of the study: The topical and systemic analgesic effects of a commercial partially purified saponin extract, 3 beta,16 alpha-dihydroxy-23-oxoolean-12-en-28-oic acid (quillaic acid), methyl 3 beta,16 alpha-dihydroxy-23-oxoolean-12-en-28-oate and methyl 4-nor-3,16-dioxoolean-12-en-28-oate., Materials and methods: The samples were assessed in mice using the topical tail-flick and i.p. hot-plate tests, respectively., Results: All the samples showed activity in both analgesic tests in a dose-dependent manner. The most active against tail flick test was commercial partially purified saponin extract (EC50 27.9 mg%, w/v) and more than the ibuprofen sodium. On hot-plate test, methyl 4-nor-3, 16-dioxoolean-12-en-28-oate was the most active (ED50 12.2 mg/kg) and more than the ibuprofen sodium., Conclusions: The results of the present study demonstrated that Quillaja saponaria saponins, quillaic acid, its methyl ester, and one of the oxidized derivatives of the latter, elicit dose-dependent antinociceptive effects in two murine thermal models.}, keywords = {activity, analgesic assay, derivatives, drugs hot-plate models, pain, quillaic quillaja saponaria, tail-flick}, pubstate = {published}, tppubtype = {article} } Ethnopharmacological relevance: Quillaja saponaria bark contains a high percentage of triterpene saponins and has been used for centuries as a cleansing and analgesic agent in Chilean folk medicine., Aim of the study: The topical and systemic analgesic effects of a commercial partially purified saponin extract, 3 beta,16 alpha-dihydroxy-23-oxoolean-12-en-28-oic acid (quillaic acid), methyl 3 beta,16 alpha-dihydroxy-23-oxoolean-12-en-28-oate and methyl 4-nor-3,16-dioxoolean-12-en-28-oate., Materials and methods: The samples were assessed in mice using the topical tail-flick and i.p. hot-plate tests, respectively., Results: All the samples showed activity in both analgesic tests in a dose-dependent manner. The most active against tail flick test was commercial partially purified saponin extract (EC50 27.9 mg%, w/v) and more than the ibuprofen sodium. On hot-plate test, methyl 4-nor-3, 16-dioxoolean-12-en-28-oate was the most active (ED50 12.2 mg/kg) and more than the ibuprofen sodium., Conclusions: The results of the present study demonstrated that Quillaja saponaria saponins, quillaic acid, its methyl ester, and one of the oxidized derivatives of the latter, elicit dose-dependent antinociceptive effects in two murine thermal models. |
2011 |
Antinociceptive Activity of Quillaja Saponaria Mol. Saponin Extract, Quillaic Acid and Derivatives in Mice Artículo de revista Journal of Ethnopharmacology, 133 (1), pp. 164-167, 2011, ISSN: 0378-8741. |