2013 |
Sepulveda, B; Chamy, M C; Piovano, M; Areche, C Lichens: Might Be Considered as a Source of Gastroprotective Molecules? Artículo de revista Journal of the Chilean Chemical Society, 58 (2), pp. 1750-1752, 2013, ISSN: 0717-9707. Resumen | Enlaces | BibTeX | Etiquetas: chilean damage, depside, depsidone, extract, gastric indomethacin, lichens, mucosal neutrophil-infiltration, oxidative rats stress, ulcer, water @article{RN117, title = {Lichens: Might Be Considered as a Source of Gastroprotective Molecules?}, author = { B. Sepulveda and M.C. Chamy and M. Piovano and C. Areche}, url = {/brokenurl#<Go to ISI>://WOS:000331237700024}, issn = {0717-9707}, year = {2013}, date = {2013-01-01}, journal = {Journal of the Chilean Chemical Society}, volume = {58}, number = {2}, pages = {1750-1752}, abstract = {Lichens are symbiotic relationship between fungi and algae or cyanobacteria. Secondary metabolites from lichens are known as lichen substances. We investigated depsidone and depside from lichens 1-6 in the context of their action to prevent gastric ulcer on the model of HCl/ethanol in mice for the first time. Doses of 30 mg/kg of lichen substances 1-6 and positive control (lansoprazole) significantly diminished the lesion index compared with negative control (treated only with HCl/EtOH). Lobaric acid 1, atranorin 2 and psoromic acid 5 reduced the gastric lesions by 76%, 63% and 65%, while for variolaric acid 3, diffractaic acid 4 and perlatolic acid 6 their values were 32%, 14% and 45%, respectively. Our results suggest that lichens have potential as a suite of gastroprotective molecules.}, keywords = {chilean damage, depside, depsidone, extract, gastric indomethacin, lichens, mucosal neutrophil-infiltration, oxidative rats stress, ulcer, water}, pubstate = {published}, tppubtype = {article} } Lichens are symbiotic relationship between fungi and algae or cyanobacteria. Secondary metabolites from lichens are known as lichen substances. We investigated depsidone and depside from lichens 1-6 in the context of their action to prevent gastric ulcer on the model of HCl/ethanol in mice for the first time. Doses of 30 mg/kg of lichen substances 1-6 and positive control (lansoprazole) significantly diminished the lesion index compared with negative control (treated only with HCl/EtOH). Lobaric acid 1, atranorin 2 and psoromic acid 5 reduced the gastric lesions by 76%, 63% and 65%, while for variolaric acid 3, diffractaic acid 4 and perlatolic acid 6 their values were 32%, 14% and 45%, respectively. Our results suggest that lichens have potential as a suite of gastroprotective molecules. |
2013 |
Lichens: Might Be Considered as a Source of Gastroprotective Molecules? Artículo de revista Journal of the Chilean Chemical Society, 58 (2), pp. 1750-1752, 2013, ISSN: 0717-9707. |