Publicaciones 2011-2020

@article{RN130,
title = {Neonicotinic Analogues: Selective Antagonists for Alpha 4 Beta 2 Nicotinic Acetylcholine Receptors},
author = { M. Faundez-Parraguez and N. Farias-Rabelo and J.P. Gonz\'{a}lez-Gutierrez and A. Etcheverry-Berrios and J. Alzate-Morales and F. Adasme-Carreno and R. Varas and I. Bermudez and P. Iturriaga-Vasquez},
url = {/brokenurl#<Go to ISI>://WOS:000318318700003},
doi = {10.1016/j.bmc.2013.03.024},
issn = {0968-0896},
year = {2013},
date = {2013-01-01},
journal = {Bioorganic & Medicinal Chemistry},
volume = {21},
number = {10},
pages = {2687-2694},
publisher = {2013 Elsevier Ltd.},
abstract = {Nicotine is an agonist of nicotinic acetylcholine receptors (nAChRs) that has been extensively used as a template for the synthesis of alpha 4 beta 2-preferring nAChRs. Here, we used the N-methyl-pyrrolidine moiety of nicotine to design and synthesise novel alpha 4 beta 2-preferring neonicotinic ligands. We increased the distance between the basic nitrogen and aromatic group of nicotine by introducing an ester functionality that also mimics acetylcholine (Fig. 2). Additionally, we introduced a benzyloxy group linked to the benzoyl moiety. Although the neonicotinic compounds fully inhibited binding of both [alpha-I-125]bungarotoxin to human alpha 7 nAChRs and [H-3]cytisine to human alpha 4 beta 2 nAChRs, they were markedly more potent at displacing radioligand binding to human alpha 4 beta 2 nAChRs than to alpha 7 nAChRs. Functional assays showed that the neonicotinic compounds behave as antagonists at alpha 4 beta 2 and alpha 4 beta 2 alpha 5 nAChRs. Substitutions on the aromatic ring of the compounds produced compounds that displayed marked selectivity for alpha 4 beta 2 or alpha 4 beta 2 alpha 5 nAChRs. Docking of the compounds on homology models of the agonist binding site at the alpha 4/beta 2 subunit interfaces of alpha 4 beta 2 nAChRs suggested the compounds inhibit function of this nAChR type by binding the agonist binding site.},
keywords = {agonists, and antagonism, beta-2 binding, cytisine, docking functional modulators, nicotinic receptors, relationships, sensitivity, structure-activity subunit},
pubstate = {published},
tppubtype = {article}
}

@article{RN34e,
title = {Nmr Assignment in Regioisomeric Hydroquinones},
author = { J.A. Dobado and J.C. Gomez-Tamayo and F.G. Calvo-Flores and H. Martinez-Garcia and W. Cardona and B. Weiss-Lopez and O. Ramirez-Rodriguez and H. Pessoa-Mahana and R. Araya-Maturana},
url = {/brokenurl#<Go to ISI>://WOS:000291114500009},
doi = {10.1002/mrc.2745},
issn = {0749-1581},
year = {2011},
date = {2011-01-01},
journal = {Magnetic Resonance in Chemistry},
volume = {49},
number = {6},
pages = {358-365},
publisher = {2011 John Wiley & Sons, Ltd.},
abstract = {A set of regioisomeric pairs of tricyclic hydroquinones, analogues of antitumor 9,10-dihydroxy-4,4-dimethyl-5,8dihydroanthracen- 1(4H)-one (1) and other derivatives, were synthesized and their regiochemistry and NMR spectra assigned by using 1H-detected one-bond(C-H) HMQC and long-range C-HHMBC, in good agreement with theoretical O3LYP/Alhrichs-pVTZ calculations. The 5-hydroxymethyl derivatives (11, 15, 19) showed a 3 integral H,H coupling constant of methylene protons evidencing the presence of a seven-membered intramolecular hydrogen bonded ring, not observed for the 8-hydroxymethyl isomers.},
keywords = {basis-sets, c-13 calculations, chemical-shifts, coupling-constants, derivatives, dft, diels-alder giao, h, h-1 hmbc, hmqc, hydroquinone, nmr, o3lyp, organic-molecules, reaction, respiration, sensitivity, spin theoretical tumor-cell},
pubstate = {published},
tppubtype = {article}
}