Munoz, O; Maya, J D; Ferreira, J; Christen, P; Martin, San J; Lopez-Munoz, R; Morello, A; Kemmerling, U Medicinal Plants of Chile: Evaluation of Their Anti-Trypanosoma Cruzi Activity Artículo de revista Zeitschrift Fur Naturforschung Section C-a Journal of Biosciences, 68 (5-6), pp. 198-202, 2013, ISSN: 0939-5075. Resumen | Enlaces | BibTeX | Etiquetas: anti-trypanosoma antifeedant, chagas-disease, cruzi, drimenol, drugs, growth isodrimenin, toxicity @article{RN122,
title = {Medicinal Plants of Chile: Evaluation of Their Anti-Trypanosoma Cruzi Activity},
author = { O. Munoz and J.D. Maya and J. Ferreira and P. Christen and J. San Martin and R. Lopez-Munoz and A. Morello and U. Kemmerling},
url = {/brokenurl#<Go to ISI>://WOS:000323864600005},
issn = {0939-5075},
year = {2013},
date = {2013-01-01},
journal = {Zeitschrift Fur Naturforschung Section C-a Journal of Biosciences},
volume = {68},
number = {5-6},
pages = {198-202},
abstract = {The extracts of several plants of Central Chile exhibited anti-Trypanosoma cruzi trypomastigotes activity. Most active extracts were those obtained from Podanthus ovatifolius, Berberis microphylla, Kageneckia oblonga, and Drimys winteri. The active extract of Drimys winteri (IC50 51.2 mu g/mL) was purified and three drimane sesquiterpenes were obtained: polygodial, drimenol, and isodrimenin. Isodrimenin and drimenol were found to be active against the trypomastigote form of T cruzi with IC50 values of 27.9 and 25.1 mu M, respectively.},
keywords = {anti-trypanosoma antifeedant, chagas-disease, cruzi, drimenol, drugs, growth isodrimenin, toxicity},
pubstate = {published},
tppubtype = {article}
}
The extracts of several plants of Central Chile exhibited anti-Trypanosoma cruzi trypomastigotes activity. Most active extracts were those obtained from Podanthus ovatifolius, Berberis microphylla, Kageneckia oblonga, and Drimys winteri. The active extract of Drimys winteri (IC50 51.2 mu g/mL) was purified and three drimane sesquiterpenes were obtained: polygodial, drimenol, and isodrimenin. Isodrimenin and drimenol were found to be active against the trypomastigote form of T cruzi with IC50 values of 27.9 and 25.1 mu M, respectively. |