2014 |
Garcia-Beltran, O; Cassels, B K; Mena, N; Nunez, M; Yanez, O; Caballero, J A Coumarinylaldoxime as a Specific Sensor for Cu2+ and Its Biological Application Artículo de revista Tetrahedron Letters, 55 (4), pp. 873-876, 2014, ISSN: 0040-4039. Resumen | Enlaces | BibTeX | Etiquetas: bilayer, copper, coumarin cu2+-selectivity, derivative, design, dynamics, fluorescent lipid membranes molecular probe @article{RN193, title = {A Coumarinylaldoxime as a Specific Sensor for Cu2+ and Its Biological Application}, author = { O. Garcia-Beltran and B.K. Cassels and N. Mena and M. Nunez and O. Yanez and J. Caballero}, url = {/brokenurl#<Go to ISI>://WOS:000330604500023}, doi = {10.1016/j.tetlet.2013.12.033}, issn = {0040-4039}, year = {2014}, date = {2014-01-01}, journal = {Tetrahedron Letters}, volume = {55}, number = {4}, pages = {873-876}, publisher = {2013 Elsevier Ltd.}, abstract = {In this Letter we present a new probe, (E)-7-(diethylamino)-2-oxo-2H-chromene-3-carbaldehyde oxime (JB), which can detect Cu2+ ions in HEPES buffer under physiological conditions. Benesi-Hildebrand and Job plots demonstrate that the stoichiometry of the Cu2+ complex formed is 2:1. Possible interference with other analytes was examined, and the decrease of the fluorescence of JB at 510 nm when it reacts with Cu2+ was shown to be highly selective. This probe accumulates in the plasmalemma of human neuroblastoma SH-SY5Y cells. Molecular dynamics (MD) simulations revealed thatJB interacts with the lipid bilayer at the level of the glycerol moieties.}, keywords = {bilayer, copper, coumarin cu2+-selectivity, derivative, design, dynamics, fluorescent lipid membranes molecular probe}, pubstate = {published}, tppubtype = {article} } In this Letter we present a new probe, (E)-7-(diethylamino)-2-oxo-2H-chromene-3-carbaldehyde oxime (JB), which can detect Cu2+ ions in HEPES buffer under physiological conditions. Benesi-Hildebrand and Job plots demonstrate that the stoichiometry of the Cu2+ complex formed is 2:1. Possible interference with other analytes was examined, and the decrease of the fluorescence of JB at 510 nm when it reacts with Cu2+ was shown to be highly selective. This probe accumulates in the plasmalemma of human neuroblastoma SH-SY5Y cells. Molecular dynamics (MD) simulations revealed thatJB interacts with the lipid bilayer at the level of the glycerol moieties. |
2014 |
A Coumarinylaldoxime as a Specific Sensor for Cu2+ and Its Biological Application Artículo de revista Tetrahedron Letters, 55 (4), pp. 873-876, 2014, ISSN: 0040-4039. |