2016 |
Polo, E; Trilleras, J; Ramos, J; Galdámez, A; Quiroga, J; Gutierrez, M Efficient Mw-Assisted Synthesis, Spectroscopic Characterization, X-Ray and Antioxidant Properties of Indazole Derivatives Artículo de revista Molecules, 21 (7), 2016, ISSN: 1420-3049. Resumen | Enlaces | BibTeX | Etiquetas: antioxidant chemistry, discovery, drug green heterocyclic impact, inhibitors, irradiation, microwave microwave, modern organic-synthesis, pyrazoles, synthesis, tetrahydroindazole @article{RN311, title = {Efficient Mw-Assisted Synthesis, Spectroscopic Characterization, X-Ray and Antioxidant Properties of Indazole Derivatives}, author = { E. Polo and J. Trilleras and J. Ramos and A. Gald\'{a}mez and J. Quiroga and M. Gutierrez}, url = {/brokenurl#<Go to ISI>://WOS:000381509700087}, doi = {UNSP 903, 10.3390/molecules21070903}, issn = {1420-3049}, year = {2016}, date = {2016-01-01}, journal = {Molecules}, volume = {21}, number = {7}, abstract = {A small series of tetrahydroindazoles was prepared, starting from 2-acetylcyclohexanone and different hydrazines using reflux and a focused microwave reactor. Microwave irradiation (MW) favored the formation of the desired products with improved yields and shortened reaction times. This is a simple and green method for the synthesis of substituted tetrahydroindazole derivatives. The in vitro antioxidant activity was evaluated using the DPPH and ABTS methods. In these assays, 2-(4-fluorophenyl)-3-methyl-4,5,6,7-tetrahydro-2H-indazole (3f) showed moderate DPPH decoloring activity, while 3-methyl-4,5,6,7-tetrahydro-1H-indazole (3a), 3-methyl-2-phenyl-4,5,6,7-tetrahydro-2H-indazole (3b) and 2-(4-fluorophenyl)-3-methyl-4,5,6,7-tetrahydro-2H-indazole (3f) were the most active in the ABTS assay. All compounds were well characterized by IR, H-1-, C-13-NMR and GC-MS spectroscopy and physical data, while the structure of 4-(3-methyl-4,5,6,7-tetrahydro-2H-indazol-2-yl)benzoic acid (3e) was also determined by single crystal X-ray analysis.}, keywords = {antioxidant chemistry, discovery, drug green heterocyclic impact, inhibitors, irradiation, microwave microwave, modern organic-synthesis, pyrazoles, synthesis, tetrahydroindazole}, pubstate = {published}, tppubtype = {article} } A small series of tetrahydroindazoles was prepared, starting from 2-acetylcyclohexanone and different hydrazines using reflux and a focused microwave reactor. Microwave irradiation (MW) favored the formation of the desired products with improved yields and shortened reaction times. This is a simple and green method for the synthesis of substituted tetrahydroindazole derivatives. The in vitro antioxidant activity was evaluated using the DPPH and ABTS methods. In these assays, 2-(4-fluorophenyl)-3-methyl-4,5,6,7-tetrahydro-2H-indazole (3f) showed moderate DPPH decoloring activity, while 3-methyl-4,5,6,7-tetrahydro-1H-indazole (3a), 3-methyl-2-phenyl-4,5,6,7-tetrahydro-2H-indazole (3b) and 2-(4-fluorophenyl)-3-methyl-4,5,6,7-tetrahydro-2H-indazole (3f) were the most active in the ABTS assay. All compounds were well characterized by IR, H-1-, C-13-NMR and GC-MS spectroscopy and physical data, while the structure of 4-(3-methyl-4,5,6,7-tetrahydro-2H-indazol-2-yl)benzoic acid (3e) was also determined by single crystal X-ray analysis. |
2016 |
Efficient Mw-Assisted Synthesis, Spectroscopic Characterization, X-Ray and Antioxidant Properties of Indazole Derivatives Artículo de revista Molecules, 21 (7), 2016, ISSN: 1420-3049. |