2014 |
Areche, C; Sepulveda, B; Martin, San A; Garcia-Beltran, O; Simirgiotis, M; Canete, A An Unusual Mulinane Diterpenoid from the Chilean Plant Azorella Trifurcata (Gaertn) Pers Artículo de revista Organic & Biomolecular Chemistry, 12 (33), pp. 6406-6413, 2014, ISSN: 1477-0520. Resumen | Enlaces | BibTeX | Etiquetas: compacta, cytoprotection, defense, madreporica, mucosal natural-products, skeleton @article{RN183, title = {An Unusual Mulinane Diterpenoid from the Chilean Plant Azorella Trifurcata (Gaertn) Pers}, author = { C. Areche and B. Sepulveda and A. San Martin and O. Garcia-Beltran and M. Simirgiotis and A. Canete}, url = {/brokenurl#<Go to ISI>://WOS:000340437800014}, doi = {10.1039/c4ob00966e}, issn = {1477-0520}, year = {2014}, date = {2014-01-01}, journal = {Organic & Biomolecular Chemistry}, volume = {12}, number = {33}, pages = {6406-6413}, abstract = {Four new mulinane-type diterpenoids besides the known compounds mulin-11,13-dien-20-oic acid, 13 alpha-hydroxyazorellane, 13 beta-hydroxyazorellane, mulinolic acid, azorellanol, and mulin-11,13-dien-18-acetoxy-16,20-dioic acid were isolated from the Chilean plant Azorella trifurcata. One of the new metabolites isolated, 7 alpha-acetoxy-9-epi-13 beta-hydroxymulinane, possesses a new trans-syn-trans arrangement in a tricyclic ring system not previously encountered in nature. Among the mulinane diterpenoids isolated, mulin-11,13-dien-20-oic acid showed the gastroprotective effect on HCl-EtOH-induced gastric lesions in mice (ED50 = 55mg kg(-1)). Regarding the mode of gastroprotective action for this active compound, its effect was reduced by pre-treatment of the mice with indomethacin and N-ethylmaleimide, suggesting that prostaglandins and sulfhydryl compounds are positively involved in the gastroprotective activity using this model.}, keywords = {compacta, cytoprotection, defense, madreporica, mucosal natural-products, skeleton}, pubstate = {published}, tppubtype = {article} } Four new mulinane-type diterpenoids besides the known compounds mulin-11,13-dien-20-oic acid, 13 alpha-hydroxyazorellane, 13 beta-hydroxyazorellane, mulinolic acid, azorellanol, and mulin-11,13-dien-18-acetoxy-16,20-dioic acid were isolated from the Chilean plant Azorella trifurcata. One of the new metabolites isolated, 7 alpha-acetoxy-9-epi-13 beta-hydroxymulinane, possesses a new trans-syn-trans arrangement in a tricyclic ring system not previously encountered in nature. Among the mulinane diterpenoids isolated, mulin-11,13-dien-20-oic acid showed the gastroprotective effect on HCl-EtOH-induced gastric lesions in mice (ED50 = 55mg kg(-1)). Regarding the mode of gastroprotective action for this active compound, its effect was reduced by pre-treatment of the mice with indomethacin and N-ethylmaleimide, suggesting that prostaglandins and sulfhydryl compounds are positively involved in the gastroprotective activity using this model. |
2014 |
An Unusual Mulinane Diterpenoid from the Chilean Plant Azorella Trifurcata (Gaertn) Pers Artículo de revista Organic & Biomolecular Chemistry, 12 (33), pp. 6406-6413, 2014, ISSN: 1477-0520. |