2015 |
Delgado, R A; Galdámez, A; Villena, J; Reveco, P G; Thomet, F A Synthesis, Characterization and in Vitro Biological Evaluation of [Ru(Eta(6)-Arene)(N,N)Cl] Pf6 Compounds Using the Natural Products Arenes Methylisoeugenol and Anethole Artículo de revista Journal of Organometallic Chemistry, 782 , pp. 131-137, 2015, ISSN: 0022-328x. Resumen | Enlaces | BibTeX | Etiquetas: bond cancer, complexes, cytotoxicity, diastereomers, drugs, isomerization, natural ovarian oxaliplatin, products, single-crystal, tumor-models @article{RN259, title = {Synthesis, Characterization and in Vitro Biological Evaluation of [Ru(Eta(6)-Arene)(N,N)Cl] Pf6 Compounds Using the Natural Products Arenes Methylisoeugenol and Anethole}, author = { R.A. Delgado and A. Gald\'{a}mez and J. Villena and P.G. Reveco and F.A. Thomet}, url = {/brokenurl#<Go to ISI>://WOS:000351637900020}, doi = {10.1016/j.jorganchem.2014.09.005}, issn = {0022-328x}, year = {2015}, date = {2015-01-01}, journal = {Journal of Organometallic Chemistry}, volume = {782}, pages = {131-137}, publisher = {2014 Elsevier B.V.}, abstract = {Five new organometallic Ru(II) compounds (VI-X) with the general formula [Ru(eta(6)-arene)(N,N)CI]PF6, where arene-N,N correspond to methylisoeugenol-bipyridine (VI); anethole-bipyridine (VII); methylisoeugenol-ethylenediamine (VIII); anethole-ethylenediamine (IX) and methylisoeugenol-1,2-diaminobenzene (X), have been synthesized, fully characterized and biologically evaluated in vitro. The reaction conditions based on the reduction of [Ru(1,5-COD)Cl-2](n) in situ with methyleugenol and estragole, which are natural ligands, induced an alkene isomerization on the allylic substituent of coordinated arenes. The Ru(II)-arene bond formation and isomerization of the C=C bond on the allyl substituent was confirmed using 1H NMR spectroscopy; this result was validated for compound VIII by X-ray diffraction. An XRD analysis revealed the presence of both enantiomers of the complex in the single-crystal. Compounds IX and X exhibited a better cytotoxic activity in vitro than carboplatin, which is a commercial drug, against three human tumor cell lines (MCF-7, PC-3 and HT-29).}, keywords = {bond cancer, complexes, cytotoxicity, diastereomers, drugs, isomerization, natural ovarian oxaliplatin, products, single-crystal, tumor-models}, pubstate = {published}, tppubtype = {article} } Five new organometallic Ru(II) compounds (VI-X) with the general formula [Ru(eta(6)-arene)(N,N)CI]PF6, where arene-N,N correspond to methylisoeugenol-bipyridine (VI); anethole-bipyridine (VII); methylisoeugenol-ethylenediamine (VIII); anethole-ethylenediamine (IX) and methylisoeugenol-1,2-diaminobenzene (X), have been synthesized, fully characterized and biologically evaluated in vitro. The reaction conditions based on the reduction of [Ru(1,5-COD)Cl-2](n) in situ with methyleugenol and estragole, which are natural ligands, induced an alkene isomerization on the allylic substituent of coordinated arenes. The Ru(II)-arene bond formation and isomerization of the C=C bond on the allyl substituent was confirmed using 1H NMR spectroscopy; this result was validated for compound VIII by X-ray diffraction. An XRD analysis revealed the presence of both enantiomers of the complex in the single-crystal. Compounds IX and X exhibited a better cytotoxic activity in vitro than carboplatin, which is a commercial drug, against three human tumor cell lines (MCF-7, PC-3 and HT-29). |
2015 |
Synthesis, Characterization and in Vitro Biological Evaluation of [Ru(Eta(6)-Arene)(N,N)Cl] Pf6 Compounds Using the Natural Products Arenes Methylisoeugenol and Anethole Artículo de revista Journal of Organometallic Chemistry, 782 , pp. 131-137, 2015, ISSN: 0022-328x. |