Publicaciones 2011-2020

@article{RN10012,
title = {A DFT analysis of the relationships between electronic structure and affinity for dopamine D2, D3 and D4 receptor subtypesin a group of 77-LH-28-1 derivatives},
author = {J.S. Gomez-Jeria and N. Garrido-Saez},
issn = {2455-8990},
year = {2019},
date = {2019-01-01},
journal = {Chemistry Research Journal,},
volume = {4},
pages = {30-42},
publisher = {Leon Publications},
abstract = {We have studied the relationships between electronic structure and affinity for D2, D3 and D4 dopamine receptor subtypesin a group of 1-[3-(4-butylpiperidin-1-yl)propyl]-1,2,3,4-tetrahydroquinolin-2-one (77-LH-28-1) derivatives. The Klopman-Peradejordi-Gomez method was employed. Statistically significant results were obtained for all the cases. The analysis of the resulting equations provided data that can be used to design new derivatives with enhanced affinity through appropriate substitutions at selected atoms.},
keywords = {77-LH-28-1, D2 receptor, D3 receptor, D4 receptor, dft, dopamine, electronic structure, KPG method, qsar, receptor affinity},
pubstate = {published},
tppubtype = {article}
}