Publicaciones 2011-2020

@article{RN390,
title = {Blue-Fluorescent Probes for Lipid Droplets Based on Dihydrochromeno-Fused Pyrazolo- and Pyrrolopyridines},
author = { M. Becerra-Ruiz and V. Vargas and P. Jara and C. Tirapegui and C. Carrasco and M. Nunez and N. Lezana and A. Gald\'{a}mez and M. Vilches-Herrera},
url = {/brokenurl#<Go to ISI>://WOS:000444540900018},
doi = {10.1002/ejoc.201701633},
issn = {1434-193x},
year = {2018},
date = {2018-01-01},
journal = {European Journal of Organic Chemistry},
volume = {10.1002/ejoc.201701633},
number = {34},
pages = {4795-4801},
abstract = {Lipid droplets (LDs) have been recognized as highly dynamic cellular organelles involved in important biological functions for the survival of organisms such as supplying food or energy. Nevertheless, lipid storage must be tightly controlled, because both its excess and the inability to store lipids can be detrimental to the organism, resulting in metabolic diseases or multifaceted systemic problems. Visualization and the monitoring of the concentration of LDs is essential to understanding these processes. Commercially available LD dyes, such as Nile Red and boron-dipyrromethene (BODIPY), offer several advantageous characteristics, but can be limiting in multicolor imaging because most ready-made fluorescent reporter constructs fluoresce in the green-to-red region of the visible spectrum. Nile Red emits between green and red, and BODIPY can be photoconverted from green to red fluorescence, limiting its ability to be utilized for time-lapse imaging of living cells. Here, we report the design and synthesis, the photophysical characterization, and biological testing of two easily prepared series of new blue-fluorescing dyes as markers for LDs. Confocal fluorescence microscopy results showed an interesting correlation between the chemical structures of these fluorescent probes and their specific staining patterns. The pyrazole-based compound 11c was found to be a specific dye for LDs, whereas the pyrrole-based compound 10d led to prominent staining of the membranous cell organelles.},
keywords = {derivatives, design, diels-alder dyes, fluorescent fused-ring heterocycles, lipids, nitrogen photophysics, probes, prodrugs, reactions, red solvent, systems},
pubstate = {published},
tppubtype = {article}
}

@article{RN324,
title = {Effect of Shape and Bending Modulus on the Properties of Nematic Lyotropic Liquid Crystals},
author = { A. Ruiz-Fernandez and J.J. Lopez-Cascales and J.J. Giner-Casares and R. Araya-Maturana and F.G. Diaz-Banose and D. Munoz-Gacitua and B. Weiss-Lopez},
url = {/brokenurl#<Go to ISI>://WOS:000369515500071},
doi = {10.1039/c5ra24019k},
year = {2016},
date = {2016-01-01},
journal = {Rsc Advances},
volume = {6},
number = {9},
pages = {7455-7464},
abstract = {Synovial liquid is a natural lubricant of articular joints, such as shoulders, knees and hips. Thus, the development of biocompatible lubricants that can be employed in medical prosthesis for artificial implants, and eventually in certain therapies against osteo-arthritis or rheumatoid-arthritis diseases, is of an undoubted importance. Lyotropic liquid crystals have been used in the synthesis of silica and metals containing regularly oriented nanoporous, to obtain oriented carbon nanotube materials, in several pharmaceutical applications, as membrane mimetics and in lubrication applications. In this context, a new nematic lyotropic liquid crystal has been developed based on tetradecyltrimethyl ammonium chloride (TTAC), decanol (DeOH), a natural mixture of lipids (PL) extracted from soybean and sodium chloride (NaCl), all dissolved in water. A 30% w/w increase in TTAC content respect a certain composition of reference produces a more than 24-fold increase in the macroscopic viscosity of the solution. To understand the molecular principles that explain this behavior, several experimental and theoretical studies have been carried out. In this regard, H-2-NMR quadrupole splittings of fully deuterated sodium dodecyl sulphate (SDS-d(25)) introduced as molecular probe, transmission electron microscopy (TEM), freeze fracture transmission electron microscopy (FF-TEM), cryogenic transmission electron microscopy (Cryo-TEM) and polarized light microscopy (PLM) were obtained. In addition, hydrodynamic studies determined how the enhancement in viscosity requires a change in the shape of the aggregate, from circular to elliptic. Finally, molecular dynamics simulations allowed to estimate how variations in the bending modulus, k(b), can explain the observed tendency of the quadrupole splittings, on the basis of a modification in the flexibility of the aggregate.},
keywords = {bilayers, carbon ewald, h-2 lubrication, macromolecules, matter, mesh molecular-dynamics nanotubes, particle rigidity, simulations, systems},
pubstate = {published},
tppubtype = {article}
}

@article{mendizabal2011theoretical,
title = {Theoretical Study of the Protonation of [Pt-3(Mu-L)(3)(L ')(3)] (L = Co, So2, Cnh; L ' = Ph3, Cnh)},
author = { F. Mendizabal and D. Donoso and D. Burgos},
url = {/brokenurl#<Go to ISI>://WOS:000295831700035},
doi = {10.1016/j.cplett.2011.08.068},
issn = {0009-2614},
year = {2011},
date = {2011-01-01},
journal = {Chemical Physics Letters},
volume = {514},
number = {4-6},
pages = {374-378},
publisher = {2011 Elsevier B. V.},
abstract = {Ab initio calculations suggest that a series of clusters of the [Pt-3(mu-L)(3)(L')(3)(mu(3)-H](+) type (L = CO, SO2, CNH; L' = PH3, CNH) are stable. We have studied these clusters at the HF, MP2, B3LYP, PBE and TPSS theory levels. The magnitude of the interaction energies and distances indicates a substantial covalent character of the Pt-3-H bond, confirmed by orbital diagrams. In addition, the Fukui index of electrophilic attack and electrophilicity index on the unprotonated clusters were used to explore possible sites where chemical reactivity may play a role.},
keywords = {approximation, chemistry, cluster complexes, electrophilicity hydride, index, molecules, systems, units},
pubstate = {published},
tppubtype = {article}
}