Publicaciones 2011-2020

@article{RN364,
title = {Development of an Iron-Selective Antioxidant Probe with Protective Effects on Neuronal Function},
author = { O. Garcia-Beltran and N.P. Mena and P. Aguirre and G. Barriga-Gonz\'{a}lez and A. Gald\'{a}mez and E. Nagles and T. Adasme and C. Hidalgo and M. Nunez},
url = {/brokenurl#<Go to ISI>://WOS:000417648600030},
doi = {10.1371/journal.pone.0189043},
issn = {1932-6203},
year = {2017},
date = {2017-01-01},
journal = {Plos One},
volume = {12},
number = {12},
abstract = {Iron accumulation, oxidative stress and calcium signaling dysregulation are common pathognomonic signs of several neurodegenerative diseases, including Parkinson's and Alzheimer's diseases, Friedreich ataxia and Huntington's disease. Given their therapeutic potential, the identification of multifunctional compounds that suppress these damaging features is highly desirable. Here, we report the synthesis and characterization of N-(1,3-dihydroxy- 2-(hydroxymethyl) propan-2-yl)-2-(7-hydroxy-2-oxo-2H-chromen-4-yl) acetamide, named CT51, which exhibited potent free radical neutralizing activity both in vitro and in cells. CT51 bound Fe2+ with high selectivity and Fe3+ with somewhat lower affinity. Cyclic voltammetric analysis revealed irreversible binding of Fe3+ to CT51, an important finding since stopping Fe2+/Fe3+ cycling in cells should prevent hydroxyl radical production resulting from the Fenton-Haber-Weiss cycle. When added to human neuroblastoma cells, CT51 freely permeated the cell membrane and distributed to both mitochondria and cytoplasm. Intracellularly, CT51 bound iron reversibly and protected against lipid peroxidation. Treatment of primary hippocampal neurons with CT51 reduced the sustained calcium release induced by an agonist of ryanodine receptor-calcium channels. These protective properties of CT51 on cellular function highlight its possible therapeutic use in diseases with significant oxidative, iron and calcium dysregulation.},
keywords = {calcium cells, coumarins, deficiency, fluorescence fluorescence, fragmentation, iron, labile mitochondrial on oxidative parkinsons-disease, probes, sh-sy5y stress},
pubstate = {published},
tppubtype = {article}
}

@article{RN285,
title = {Gastroprotective Activity of Synthetic Coumarins: Role of Endogenous Prostaglandins, Nitric Oxide, Non-Protein Sulfhydryls and Vanilloid Receptors},
author = { B. Sepulveda and C. Quispe and M. Simirgiotis and A. Torres-Benitez and J. Reyes-Ortiz and C. Areche and O. Garcia-Beltran},
url = {/brokenurl#<Go to ISI>://WOS:000389519100023},
doi = {10.1016/j.bmcl.2016.10.056},
issn = {0960-894x},
year = {2016},
date = {2016-01-01},
journal = {Bioorganic & Medicinal Chemistry Letters},
volume = {26},
number = {23},
pages = {5732-5735},
publisher = {2016 Elsevier Ltd.},
abstract = {Natural or synthetic coumarins showed gastroprotective and antiulcer activity in animal models. In this study, we have synthetized twenty coumarins using classic methods to evaluate their gastroprotective effects on the ethanol/HCl-induced gastric lesion model in mice at 20 mg/kg. Among the coumarins synthetized, compounds 6 and 10 showed the greatest gastroprotective activity being as active as lansoprazole at 20 mg/kg and reducing gastric lesions by 75 and 76%, respectively. Then, in a second experiment, compounds 6 and 10 were re-evaluated in order to understand the possible mode of gastroprotective activity. Regarding coumarin 6, the protective effect was reduced by pre-treatment of the mice with N-ethylmaleimide and l-NAME suggesting that sulfhydryl compounds and endogenous nitric oxide are involved in its gastroprotective activity. While for coumarin 10 the effect was reduced by pre-treatment with indomethacin suggesting that prostaglandins are positively involved in its gastroprotective activity.},
keywords = {anhydrase applications, carbonic-anhydrases, coumarins, cysteine, defense derivatives, gastroprotective, glutathione, heck heterocycles, i, inhibition, isozymes reaction, scaffold, therapeutic ulcer},
pubstate = {published},
tppubtype = {article}
}

@article{RN26b,
title = {Hydrogen-Bonded Supramolecular Array in the Crystal Structure of Ethyl 7-Hydroxy-2-Oxo-2h-Chromene-3-Carboxylate Monohydrate},
author = {A. Gald\'{a}mez and O. Garcia-Beltran and B.K. Cassels},
url = {/brokenurl#<Go to ISI>://WOS:000290700500005},
doi = {10.4067/S0717-97072011000100005},
issn = {0717-9324},
year = {2011},
date = {2011-01-01},
journal = {Journal of the Chilean Chemical Society},
volume = {56},
number = {1},
pages = {546-548},
abstract = {The crystal structure of ethyl 7-hydroxy-2-oxo-2H-chromene-3-carboxylate monohydrate (1), C(12)H(10)O(5).H(2)O, was established by X-ray crystallographic analysis. The molecule of the title compound is essentially planar except for the carboxylate substituent group. The crystal packing supramolecular array arises from hydrogen bonds and intermolecular C-H center dot center dot center dot O=C contacts of the organic molecules and solvent water molecules, with graph-Set descriptor R(4)(2)(8), R(1)(2) (6), R(4)(4)(20) and C(5) motifs. The water molecules are involved as donors and acceptors. The hydrogen bond and intermolecular interaction network is reinforced by stacking of the sheet through pi-pi interactions.},
keywords = {coumarins, crystal design diffraction, patterns, structure, x-ray},
pubstate = {published},
tppubtype = {article}
}