Publicaciones 2011-2020

@article{RN345,
title = {Synthesis, Scope, H-1 and C-13 Spectral Assignments of Isomeric Dibenzofuran Carboxaldehydes},
author = { T. Yempala and B.K. Cassels},
url = {/brokenurl#<Go to ISI>://WOS:000394374600002},
doi = {10.1007/s11164-016-2698-1},
issn = {0922-6168},
year = {2017},
date = {2017-01-01},
journal = {Research on Chemical Intermediates},
volume = {43},
number = {3},
pages = {1291-1299},
abstract = {Two isomeric dibenzofuran carboxaldehydes, namely 2-methoxydibenzo[b,d]furan-1-carbaldehyde (4) and 2-methoxydibenzo[b,d]furan-3-carbaldehyde (5), were synthesized. Formylation of 2-methoxydibenzo[b,d]furan (3) with alpha,alpha-dichloromethyl methyl ether and tin(IV) chloride gave a mixture of aldehydes 4 and 5 in 95 % yield and in a 35:65 ratio. Their H-1 and C-13 NMR spectral signals were not sufficiently resolved in CDCl3 solution to achieve their complete assignment, but this was possible in DMSO-d (6) with the help of 2D-NMR techniques: NOESY for H-1-H-1 interactions and HSQC and HMQC experiments for H-1-C-13 correlations. These aldehydes were used in the synthesis of novel beta-phenylethylamines and NBOMe derivatives, which are undergoing biological evaluation.},
keywords = {beta-phenylethylamines bond c-13, copd, d]furan aldehyde and arylation, derivatives, design direct discovery, formation, h-1, inhibitors, nbome nmr, potential pulmonary-disease receptors, regioisomers, serotonin, treatment},
pubstate = {published},
tppubtype = {article}
}

@article{RN337,
title = {Rosmarinic Acid Prevents Fibrillization and Diminishes Vibrational Modes Associated to Beta Sheet in Tau Protein Linked to Alzheimer's Disease},
author = { A. Cornejo and F.A. Sandoval and L. Caballero and L. Machuca and P. Munoz and J. Caballero and G. Perry and A. Ardiles and C. Areche and F. Melo},
url = {/brokenurl#<Go to ISI>://WOS:000406130000006},
doi = {10.1080/14756366.2017.1347783},
issn = {1475-6366},
year = {2017},
date = {2017-01-01},
journal = {Journal of Enzyme Inhibition and Medicinal Chemistry},
volume = {32},
number = {1},
pages = {945-953},
abstract = {Alzheimer's disease is a common tauopathy where fibril formation and aggregates are the hallmark of the disease. Efforts targeting amyloid-beta plaques have succeeded to remove plaques but failed in clinical trials to improve cognition; thus, the current therapeutic strategy is at preventing tau aggregation. Here, we demonstrated that four phenolic diterpenoids and rosmarinic acid inhibit fibrillization. Since, rosmarinic acid was the most active compound, we observe morphological changes in atomic force microscopy images after treatment. Hence, rosmarinic acid leads to a decrease in amide regions I and III, indicating that rosmarinic acid prevents beta-sheet assembly. Molecular docking study inside the steric zipper model of the hexapeptide (306)VQIVYK(311) involved in fibrillization and beta sheet formation, suggests that rosmarinic acid binds to the steric zipper with similar chemical interactions with respect to those observed for orange G, a known pharmacofore for amyloid.},
keywords = {alzheimer's amyloid beta-sheet, carnosic cells criteria, disease, fibril filaments, formation, helical in-vitro, inhibition, inhibitors, mice, neuropathologic paired pharmacophore, salvia-officinalis, tau transgenic},
pubstate = {published},
tppubtype = {article}
}

@article{RN311,
title = {Efficient Mw-Assisted Synthesis, Spectroscopic Characterization, X-Ray and Antioxidant Properties of Indazole Derivatives},
author = { E. Polo and J. Trilleras and J. Ramos and A. Gald\'{a}mez and J. Quiroga and M. Gutierrez},
url = {/brokenurl#<Go to ISI>://WOS:000381509700087},
doi = {UNSP 903, 10.3390/molecules21070903},
issn = {1420-3049},
year = {2016},
date = {2016-01-01},
journal = {Molecules},
volume = {21},
number = {7},
abstract = {A small series of tetrahydroindazoles was prepared, starting from 2-acetylcyclohexanone and different hydrazines using reflux and a focused microwave reactor. Microwave irradiation (MW) favored the formation of the desired products with improved yields and shortened reaction times. This is a simple and green method for the synthesis of substituted tetrahydroindazole derivatives. The in vitro antioxidant activity was evaluated using the DPPH and ABTS methods. In these assays, 2-(4-fluorophenyl)-3-methyl-4,5,6,7-tetrahydro-2H-indazole (3f) showed moderate DPPH decoloring activity, while 3-methyl-4,5,6,7-tetrahydro-1H-indazole (3a), 3-methyl-2-phenyl-4,5,6,7-tetrahydro-2H-indazole (3b) and 2-(4-fluorophenyl)-3-methyl-4,5,6,7-tetrahydro-2H-indazole (3f) were the most active in the ABTS assay. All compounds were well characterized by IR, H-1-, C-13-NMR and GC-MS spectroscopy and physical data, while the structure of 4-(3-methyl-4,5,6,7-tetrahydro-2H-indazol-2-yl)benzoic acid (3e) was also determined by single crystal X-ray analysis.},
keywords = {antioxidant chemistry, discovery, drug green heterocyclic impact, inhibitors, irradiation, microwave microwave, modern organic-synthesis, pyrazoles, synthesis, tetrahydroindazole},
pubstate = {published},
tppubtype = {article}
}

@article{RN258,
title = {The Synthesis of C-2 Symmetry Diesters of (3r,4r)-Ttfol through a Green and Stereoselective (2r,3r)-Taddol Rearrangement},
author = { A.R. Costantino and M.G.M. Schneider and A. Galdamez and R.A. Ocampo and S.D. Mandolesi and L.C. Koll},
url = {/brokenurl#<Go to ISI>://WOS:000366070000005},
doi = {10.1016/j.tetasy.2015.10.014},
issn = {0957-4166},
year = {2015},
date = {2015-01-01},
journal = {Tetrahedron-Asymmetry},
volume = {26},
number = {23},
pages = {1341-1347},
publisher = {2015 Elsevier Ltd.},
abstract = {An efficient, green, and atom economic methodology for the stereoselective synthesis of C-2 symmetry (3R,4R)-TTFOL diester derivatives has been developed. The procedure occurs through a (2R,3R)-TADDOL dioxolane cleavage and rearrangement under mild conditions by its reaction with a carboxylic acid in the presence of TFAA/H3PO4 without the need for an inert atmosphere to give generally high yields.},
keywords = {analogs, anhydrides carboxylic-acids, derivatives, esterification, esters, in-situ, inhibitors, integrase ligands, taddol},
pubstate = {published},
tppubtype = {article}
}

@article{RN215,
title = {Intramolecular Hydrogen Bond in Biologically Active O-Carbonyl Hydroquinones},
author = { M. Martinez-Cifuentes and B. Weiss-Lopez and L.S. Santos and R. Araya-Maturana},
url = {/brokenurl#<Go to ISI>://WOS:000340036200041},
doi = {10.3390/molecules19079354},
issn = {1420-3049},
year = {2014},
date = {2014-01-01},
journal = {Molecules},
volume = {19},
number = {7},
pages = {9354-9368},
abstract = {Intramolecular hydrogen bonds (IHBs) play a central role in the molecular structure, chemical reactivity and interactions of biologically active molecules. Here, we study the IHBs of seven related o-carbonyl hydroquinones and one structurally-related aromatic lactone, some of which have shown anticancer and antioxidant activity. Experimental NMR data were correlated with theoretical calculations at the DFT and ab initio levels. Natural bond orbital (NBO) and molecular electrostatic potential (MEP) calculations were used to study the electronic characteristics of these IHB. As expected, our results show that NBO calculations are better than MEP to describe the strength of the IHBs. NBO energies (Delta E-ij((2))) show that the main contributions to energy stabilization correspond to LP ->sigma* interactions for IHBs, (O1O2)-O-center dot center dot center dot-H-2 and the delocalization LP ->pi* for O-2-C-2 = C-alpha(beta). For the (O1O2)-O-center dot center dot center dot-H-2 interaction, the values of Delta E-ij((2)) can be attributed to the difference in the overlap ability between orbitals i and j (F-ij), instead of the energy difference between them. The large energy for the LP O-2 ->pi* C-2 = C-alpha(beta) interaction in the compounds 9-Hydroxy-5-oxo-4,8, 8-trimethyl-1, 9(8H)-anthracenecarbolactone (VIII) and 9,10-dihydroxy-4,4-dimethylanthracen-1(4H)-one (VII) (55.49 and 60.70 kcal/mol, respectively) when compared with the remaining molecules (all less than 50 kcal/mol), suggests that the IHBs in VIII and VII are strongly resonance assisted.},
keywords = {ab-initio, bond bond, chemistry, derivatives, dft, diels-alder electrostatic hydrogen hydroquinone, inhibitors, molecular molecules, natural orbital, potential, quinones, radicals reaction, resonance, respiration, tumor-cell},
pubstate = {published},
tppubtype = {article}
}

@article{RN181,
title = {Concise and Straightforward Asymmetric Synthesis of a Cyclic Natural Hydroxy-Amino Acid},
author = { M.J. Simirgiotis and J. Vallejos and C. Areche and B. Sepulveda},
url = {/brokenurl#<Go to ISI>://WOS:000346793200014},
doi = {10.3390/molecules191219516},
issn = {1420-3049},
year = {2014},
date = {2014-01-01},
journal = {Molecules},
volume = {19},
number = {12},
pages = {19516-19531},
abstract = {An enantioselective total synthesis of the natural amino acid (2S,4R,5R)-4,5-di-hydroxy-pipecolic acid starting from D-glucoheptono-1, 4-lactone is presented. The best sequence employed as a keywords step the intramolecular nucleophilic displacement by an amino function of a 6-O-p-toluene-sulphonyl derivative of a methyl D-arabino-hexonate and involved only 12 steps with an overall yield of 19%. The structures of the compounds synthesized were elucidated on the basis of comprehensive spectroscopic (NMR and MS) and computational analysis.},
keywords = {amino analogs, derivatives, inhibitors, pipecolic piperidine, protease seeds synthesis, total},
pubstate = {published},
tppubtype = {article}
}