Publicaciones 2011-2020

@article{RN197,
title = {Improving Amphetamine Therapeutic Selectivity: N,N-Dimethyl-Mta Has Dopaminergic Effects and Does Not Produce Aortic Contraction},
author = { R. Sotomayor-Zarate and P. Jara and P. Araos and R. Vinet and G. Quiroz and G.M. Renard and P. Espinosa and C. Hurtado-Guzman and P.R. Moya and P. Iturriaga-Vasquez and K. Gysling and M. Reyes-Parada},
url = {/brokenurl#<Go to ISI>://WOS:000333969800004},
doi = {10.1111/bcpt.12168},
issn = {1742-7835},
year = {2014},
date = {2014-01-01},
journal = {Basic & Clinical Pharmacology & Toxicology},
volume = {114},
number = {5},
pages = {395-399},
abstract = {Amphetamine derivatives have therapeutic potential in diseases such as attention deficit hyperactivity disorder, narcolepsy and obesity. However, their prolonged use has been associated with cardiovascular toxicity and addiction. In recent years, we have studied the pharmacological effects of amphetamine derivatives such as methylthioamphetamine (MTA) and N,N-dimethyl-thioamphetamine, with the aim of improving their therapeutic selectivity. In this work, we show that similarly to MTA, N,N-dimethyl-thioamphetamine has effects on the dopamine system, producing a significant increase in extracellular levels of dopamine (as measured by in vivo brain microdialysis) and locomotor activity, which is a behavioural measure of dopaminergic activation. However, unlike MTA, N,N-dimethyl- thioamphetamine does not produce aortic contraction in vitro. Our results show that N,N-dimethyl-thioamphetamine is a drug that retains the dopaminergic effects of amphetamine derivatives but exhibits a lower potential for producing cardiovascular side effects.},
keywords = {derivatives, dexamphetamine, dextroamphetamine, drugs, inhibitory lateral noradrenaline, oxidase properties, rat, release septum, transporters},
pubstate = {published},
tppubtype = {article}
}

@article{RN131,
title = {Synthesis, Docking and Pharmacological Evaluation of Novel Homo- and Hetero-Bis 3-Piperazinylpropylindole Derivatives at Sert and 5-Ht1a Receptor},
author = { H. Pessoa-Mahana and C. Gonz\'{a}lez-Lira and A. Fierro and G. Zapata-Torres and C.D. Pessoa-Mahana and J. Ortiz-Severin and P. Iturriaga-Vasquez and M. Reyes-Parada and P. Silva-Matus and C. Saitz-Barria and R. Araya-Maturana},
url = {/brokenurl#<Go to ISI>://WOS:000327766200007},
doi = {10.1016/j.bmc.2013.10.036},
issn = {0968-0896},
year = {2013},
date = {2013-01-01},
journal = {Bioorganic & Medicinal Chemistry},
volume = {21},
number = {24},
pages = {7604-7611},
publisher = {2013 Elsevier Ltd.},
abstract = {A series of 3-(3-(4-(3-(1H-indol-3-yl)propyl)piperazin-1-yl)propyl)-1H-indole derivatives (3a-d and 5a-f) as homo-and hetero-bis-ligands, were synthesized and evaluated for in vitro affinity at the serotonin transporter (SERT) and the 5-HT1A receptor. Compounds 5b and 5f showed nanomolar affinities for both targets. The experimental data were rationalized according to results obtained from docking experiments. These findings are in agreement with our proposal that bis-indole derivatives can bind both targets, and might serve as leads in the quest of ligands endowed with a dual mechanism of action.},
keywords = {analogs antagonists, antidepressant automated bacterial bivalent derivatives, docking, drugs, homolog, ligands, neurotransmitter piperazinylpropylindole receptor, reuptake, serotonin transporter, transporters},
pubstate = {published},
tppubtype = {article}
}