2018 |
Vilches-Herrera, M; Concha-Puelles, M; Carvajal, N; Molina, J; Santander, R; Rezende, M C; Luhr, S Influence of the Bite Natural Angle of Bidentate Diphosphine Ligands in the Syngas-Free Branched Hydroformylation of Beta-Functionalized Olefins Artículo de revista Catalysis Communications, 116 , pp. 62-66, 2018, ISSN: 1566-7367. Resumen | Enlaces | BibTeX | Etiquetas: allyl angles, asymmetric beta-functionalized bite cyanide, diphosphine formaldehyde hydroformylation, hydrogenations, ligands, natural olefins, p-op regioselectivity, rhodium-catalyzed syngas-free @article{RN391, title = {Influence of the Bite Natural Angle of Bidentate Diphosphine Ligands in the Syngas-Free Branched Hydroformylation of Beta-Functionalized Olefins}, author = { M. Vilches-Herrera and M. Concha-Puelles and N. Carvajal and J. Molina and R. Santander and M.C. Rezende and S. Luhr}, url = {/brokenurl#<Go to ISI>://WOS:000444933100013}, doi = {10.1016/j.catcom.2018.08.007}, issn = {1566-7367}, year = {2018}, date = {2018-01-01}, journal = {Catalysis Communications}, volume = {116}, pages = {62-66}, abstract = {The correlation between the activity, regio- and chemoselectivity of Rh-diphosphine catalyst and the ligand bite natural angle (beta(n)) in the syngas-free hydroformylation of allyl cyanide was investigated. A screening of Xantphos type and diphosphine alkyl ligands with different bite natural angles was studied. Interesting, a switch in the linear to the branch regioselectivity was found. Wide beta(n) favour a linear regioselectivity whereas smaller beta(n) allow the formation of the branched aldehyde as the major product. Modification of the substituents at the phosphorus atoms of the diphosphine ligands produced a dramatic change in the hydroformylation. Others beta-functionalized olefins were also branched hydroformylated.}, keywords = {allyl angles, asymmetric beta-functionalized bite cyanide, diphosphine formaldehyde hydroformylation, hydrogenations, ligands, natural olefins, p-op regioselectivity, rhodium-catalyzed syngas-free}, pubstate = {published}, tppubtype = {article} } The correlation between the activity, regio- and chemoselectivity of Rh-diphosphine catalyst and the ligand bite natural angle (beta(n)) in the syngas-free hydroformylation of allyl cyanide was investigated. A screening of Xantphos type and diphosphine alkyl ligands with different bite natural angles was studied. Interesting, a switch in the linear to the branch regioselectivity was found. Wide beta(n) favour a linear regioselectivity whereas smaller beta(n) allow the formation of the branched aldehyde as the major product. Modification of the substituents at the phosphorus atoms of the diphosphine ligands produced a dramatic change in the hydroformylation. Others beta-functionalized olefins were also branched hydroformylated. |
2013 |
Pessoa-Mahana, H; González-Lira, C; Fierro, A; Zapata-Torres, G; Pessoa-Mahana, C D; Ortiz-Severin, J; Iturriaga-Vasquez, P; Reyes-Parada, M; Silva-Matus, P; Saitz-Barria, C; Araya-Maturana, R Synthesis, Docking and Pharmacological Evaluation of Novel Homo- and Hetero-Bis 3-Piperazinylpropylindole Derivatives at Sert and 5-Ht1a Receptor Artículo de revista Bioorganic & Medicinal Chemistry, 21 (24), pp. 7604-7611, 2013, ISSN: 0968-0896. Resumen | Enlaces | BibTeX | Etiquetas: analogs antagonists, antidepressant automated bacterial bivalent derivatives, docking, drugs, homolog, ligands, neurotransmitter piperazinylpropylindole receptor, reuptake, serotonin transporter, transporters @article{RN131, title = {Synthesis, Docking and Pharmacological Evaluation of Novel Homo- and Hetero-Bis 3-Piperazinylpropylindole Derivatives at Sert and 5-Ht1a Receptor}, author = { H. Pessoa-Mahana and C. Gonz\'{a}lez-Lira and A. Fierro and G. Zapata-Torres and C.D. Pessoa-Mahana and J. Ortiz-Severin and P. Iturriaga-Vasquez and M. Reyes-Parada and P. Silva-Matus and C. Saitz-Barria and R. Araya-Maturana}, url = {/brokenurl#<Go to ISI>://WOS:000327766200007}, doi = {10.1016/j.bmc.2013.10.036}, issn = {0968-0896}, year = {2013}, date = {2013-01-01}, journal = {Bioorganic & Medicinal Chemistry}, volume = {21}, number = {24}, pages = {7604-7611}, publisher = {2013 Elsevier Ltd.}, abstract = {A series of 3-(3-(4-(3-(1H-indol-3-yl)propyl)piperazin-1-yl)propyl)-1H-indole derivatives (3a-d and 5a-f) as homo-and hetero-bis-ligands, were synthesized and evaluated for in vitro affinity at the serotonin transporter (SERT) and the 5-HT1A receptor. Compounds 5b and 5f showed nanomolar affinities for both targets. The experimental data were rationalized according to results obtained from docking experiments. These findings are in agreement with our proposal that bis-indole derivatives can bind both targets, and might serve as leads in the quest of ligands endowed with a dual mechanism of action.}, keywords = {analogs antagonists, antidepressant automated bacterial bivalent derivatives, docking, drugs, homolog, ligands, neurotransmitter piperazinylpropylindole receptor, reuptake, serotonin transporter, transporters}, pubstate = {published}, tppubtype = {article} } A series of 3-(3-(4-(3-(1H-indol-3-yl)propyl)piperazin-1-yl)propyl)-1H-indole derivatives (3a-d and 5a-f) as homo-and hetero-bis-ligands, were synthesized and evaluated for in vitro affinity at the serotonin transporter (SERT) and the 5-HT1A receptor. Compounds 5b and 5f showed nanomolar affinities for both targets. The experimental data were rationalized according to results obtained from docking experiments. These findings are in agreement with our proposal that bis-indole derivatives can bind both targets, and might serve as leads in the quest of ligands endowed with a dual mechanism of action. |
2018 |
Influence of the Bite Natural Angle of Bidentate Diphosphine Ligands in the Syngas-Free Branched Hydroformylation of Beta-Functionalized Olefins Artículo de revista Catalysis Communications, 116 , pp. 62-66, 2018, ISSN: 1566-7367. |
2013 |
Synthesis, Docking and Pharmacological Evaluation of Novel Homo- and Hetero-Bis 3-Piperazinylpropylindole Derivatives at Sert and 5-Ht1a Receptor Artículo de revista Bioorganic & Medicinal Chemistry, 21 (24), pp. 7604-7611, 2013, ISSN: 0968-0896. |