2018 |
Silva, N; Riveros, A; Yutronic, N; Lang, E; Chornik, B; Guerrero, S; Samitier, J; Jara, P; Kogan, M J Photothermally Controlled Methotrexate Release System Using Beta-Cyclodextrin and Gold Nanoparticles Artículo de revista Nanomaterials, 8 (12), 2018, ISSN: 2079-4991. Resumen | Enlaces | BibTeX | Etiquetas: binding, citrate complex, compound, cyclodextrin, delivery delivery, gold hepatotoxicity, inclusion irradiation, laser, methotrexate, nanoparticles, oxidative photothermal release, stabilization, stress, system, therapy @article{RN392, title = {Photothermally Controlled Methotrexate Release System Using Beta-Cyclodextrin and Gold Nanoparticles}, author = { N. Silva and A. Riveros and N. Yutronic and E. Lang and B. Chornik and S. Guerrero and J. Samitier and P. Jara and M.J. Kogan}, url = {/brokenurl#<Go to ISI>://WOS:000455323100023}, doi = {10.3390/nano8120985}, issn = {2079-4991}, year = {2018}, date = {2018-01-01}, journal = {Nanomaterials}, volume = {8}, number = {12}, abstract = {The inclusion compound (IC) of cyclodextrin (CD) containing the antitumor drug Methotrexate (MTX) as a guest molecule was obtained to increase the solubility of MTX and decrease its inherent toxic effects in nonspecific cells. The IC was conjugated with gold nanoparticles (AuNPs), obtained by a chemical method, creating a ternary intelligent delivery system for MTX molecules, based on the plasmonic properties of the AuNPs. Irradiation of the ternary system, with a laser wavelength tunable with the corresponding surface plasmon of AuNPs, causes local energy dissipation, producing the controlled release of the guest from CD cavities. Finally, cell viability was evaluated using MTS assays for beta-CD/MTX and AuNPs + beta-CD/MTX samples, with and without irradiation, against HeLa tumor cells. The irradiated sample of the ternary system AuNPs + beta-CD/MTX produced a diminution in cell viability attributed to the photothermal release of MTX.}, keywords = {binding, citrate complex, compound, cyclodextrin, delivery delivery, gold hepatotoxicity, inclusion irradiation, laser, methotrexate, nanoparticles, oxidative photothermal release, stabilization, stress, system, therapy}, pubstate = {published}, tppubtype = {article} } The inclusion compound (IC) of cyclodextrin (CD) containing the antitumor drug Methotrexate (MTX) as a guest molecule was obtained to increase the solubility of MTX and decrease its inherent toxic effects in nonspecific cells. The IC was conjugated with gold nanoparticles (AuNPs), obtained by a chemical method, creating a ternary intelligent delivery system for MTX molecules, based on the plasmonic properties of the AuNPs. Irradiation of the ternary system, with a laser wavelength tunable with the corresponding surface plasmon of AuNPs, causes local energy dissipation, producing the controlled release of the guest from CD cavities. Finally, cell viability was evaluated using MTS assays for beta-CD/MTX and AuNPs + beta-CD/MTX samples, with and without irradiation, against HeLa tumor cells. The irradiated sample of the ternary system AuNPs + beta-CD/MTX produced a diminution in cell viability attributed to the photothermal release of MTX. |
2012 |
Barrientos-Poblete, L; Allende-González, P; Orellana, C; Jara, P Ordered Arrangements of Metal Nanoparticles on Alpha-Cyclodextrin Inclusion Complexes by Magnetron Sputtering Artículo de revista Inorganica Chimica Acta, 380 , pp. 372-377, 2012, ISSN: 0020-1693. Resumen | Enlaces | BibTeX | Etiquetas: catalysis, colloids, gold guest host interaction, magnetron metal metal-guest molecules, monolayer, nanoparticles, nanostructures, particles, size, sputtering, stabilization, supramolecular surface @article{RN81, title = {Ordered Arrangements of Metal Nanoparticles on Alpha-Cyclodextrin Inclusion Complexes by Magnetron Sputtering}, author = { L. Barrientos-Poblete and P. Allende-Gonz\'{a}lez and C. Orellana and P. Jara}, url = {/brokenurl#<Go to ISI>://WOS:000300180100050}, doi = {10.1016/j.ica.2011.10.032}, issn = {0020-1693}, year = {2012}, date = {2012-01-01}, journal = {Inorganica Chimica Acta}, volume = {380}, pages = {372-377}, publisher = {2011 Elsevier B.V.}, abstract = {An ordered self-assembly of copper, silver and gold nanoparticles onto crystal faces of alpha-cyclodextrin/1-octanethiol and 2 alpha-cyclodextrin/1-octylamine inclusion complexes by means of physical vapor deposition (magnetron sputtering) has been achieved. The preferential deposition on the (001) plane of the supramolecular crystal occurs because the -SH and -NH2 groups from the guest molecules found within the alpha-cyclodextrin protrude into that plane. These functional groups form a two-dimensional hexagonal lattice that interacts with the metal nanoparticles, arranging them in an ordered way.}, keywords = {catalysis, colloids, gold guest host interaction, magnetron metal metal-guest molecules, monolayer, nanoparticles, nanostructures, particles, size, sputtering, stabilization, supramolecular surface}, pubstate = {published}, tppubtype = {article} } An ordered self-assembly of copper, silver and gold nanoparticles onto crystal faces of alpha-cyclodextrin/1-octanethiol and 2 alpha-cyclodextrin/1-octylamine inclusion complexes by means of physical vapor deposition (magnetron sputtering) has been achieved. The preferential deposition on the (001) plane of the supramolecular crystal occurs because the -SH and -NH2 groups from the guest molecules found within the alpha-cyclodextrin protrude into that plane. These functional groups form a two-dimensional hexagonal lattice that interacts with the metal nanoparticles, arranging them in an ordered way. |
2018 |
Photothermally Controlled Methotrexate Release System Using Beta-Cyclodextrin and Gold Nanoparticles Artículo de revista Nanomaterials, 8 (12), 2018, ISSN: 2079-4991. |
2012 |
Ordered Arrangements of Metal Nanoparticles on Alpha-Cyclodextrin Inclusion Complexes by Magnetron Sputtering Artículo de revista Inorganica Chimica Acta, 380 , pp. 372-377, 2012, ISSN: 0020-1693. |