Publicaciones 2011-2020

@article{RN392,
title = {Photothermally Controlled Methotrexate Release System Using Beta-Cyclodextrin and Gold Nanoparticles},
author = { N. Silva and A. Riveros and N. Yutronic and E. Lang and B. Chornik and S. Guerrero and J. Samitier and P. Jara and M.J. Kogan},
url = {/brokenurl#<Go to ISI>://WOS:000455323100023},
doi = {10.3390/nano8120985},
issn = {2079-4991},
year = {2018},
date = {2018-01-01},
journal = {Nanomaterials},
volume = {8},
number = {12},
abstract = {The inclusion compound (IC) of cyclodextrin (CD) containing the antitumor drug Methotrexate (MTX) as a guest molecule was obtained to increase the solubility of MTX and decrease its inherent toxic effects in nonspecific cells. The IC was conjugated with gold nanoparticles (AuNPs), obtained by a chemical method, creating a ternary intelligent delivery system for MTX molecules, based on the plasmonic properties of the AuNPs. Irradiation of the ternary system, with a laser wavelength tunable with the corresponding surface plasmon of AuNPs, causes local energy dissipation, producing the controlled release of the guest from CD cavities. Finally, cell viability was evaluated using MTS assays for beta-CD/MTX and AuNPs + beta-CD/MTX samples, with and without irradiation, against HeLa tumor cells. The irradiated sample of the ternary system AuNPs + beta-CD/MTX produced a diminution in cell viability attributed to the photothermal release of MTX.},
keywords = {binding, citrate complex, compound, cyclodextrin, delivery delivery, gold hepatotoxicity, inclusion irradiation, laser, methotrexate, nanoparticles, oxidative photothermal release, stabilization, stress, system, therapy},
pubstate = {published},
tppubtype = {article}
}

@article{RN327,
title = {On the Mechanism of Co2 Electro-Cycloaddition to Propylene Oxides},
author = { S. Gallardo-Fuentes and R. Contreras and M. Isaacs and J. Honores and D. Quezada and E. Landaeta and R. Ormazabal-Toledo},
url = {/brokenurl#<Go to ISI>://WOS:000389089200013},
doi = {10.1016/j.jcou.2016.06.007},
issn = {2212-9820},
year = {2016},
date = {2016-01-01},
journal = {Journal of Co2 Utilization},
volume = {16},
pages = {114-120},
publisher = {2016 Elsevier Ltd.},
abstract = {We herein present a systematic study on the mechanism of CO2 electro-cycloaddition to propylene oxide, using both experimental and theoretical procedures. The study considers the analysis of mild and sustainable conditions to obtain cyclic carbonates from CO2 recycling. Within the electrochemical approach, the application of an overpotential in the reaction enhances the reaction yield significantly with respect to the thermal pathway. The quantum-mechanical approach provides relevant information about the reaction mechanism. Specifically, the use of the Lewis acid catalyst Mg2+ in the presence of the [C(4)C(1)Im][Br] ionic liquid provides the best condition for the electro-synthesis. The theoretical predictions were confirmed by a new set of experiments.},
keywords = {atmospheric calculations, capture carbonate catalyst co2 co2, complexes, conversion, cyclic density dioxide, efficient electro-cycloaddition, electrochemical functional high-capacity, ionic liquids, mechanism, reaction recovery, reduction, salen synthesis, system},
pubstate = {published},
tppubtype = {article}
}

@article{RN270,
title = {Accuracy and Reliability of Chile's National Air Quality Information System for Measuring Particulate Matter: Beta Attenuation Monitoring Issue},
author = { A.R. Toro and C. Campos and C. Molina and R.G.E. Morales and M.A. Leiva},
url = {/brokenurl#<Go to ISI>://WOS:000357909800013},
doi = {10.1016/j.envint.2015.02.009},
issn = {0160-4120},
year = {2015},
date = {2015-01-01},
journal = {Environment International},
volume = {82},
pages = {101-109},
publisher = {2015 Elsevier Ltd.},
abstract = {A critical analysis of Chile's National Air Quality Information System (NAQIS) is presented, focusing on particulate matter (PM) measurement. This paper examines the complexity, availability and reliability of monitoring station information, the implementation of control systems, the quality assurance protocols of the monitoring station data and the reliability of the measurement systems in areas highly polluted by particulate matter. From information available on the NAQIS website, it is possible to confirm that the PM2.5 (PM10) data available on the site correspond to 30.8% (69.2%) of the total information available from the monitoring stations. There is a lack of information regarding the measurement systems used to quantify air pollutants, most of the available data registers contain gaps, almost all of the information is categorized as "preliminary information" and neither standard operating procedures (operational and validation) nor assurance audits or quality control of the measurements are reported. In contrast, events that cause saturation of the monitoring detectors located in northern and southern Chile have been observed using beta attenuation monitoring. In these cases, it can only be concluded that the PM content is equal to or greater than the saturation concentration registered by the monitors and that the air quality indexes obtained from these measurements are underestimated. This occurrence has been observed in 12 (20) public and private stations where PM2.5 (PM10) is measured. The shortcomings of the NAQIS data have important repercussions for the conclusions obtained from the data and for how the data are used. However, these issues represent opportunities for improving the system to widen its use, incorporate comparison protocols between equipment install new stations and standardize the control system and quality assurance.},
keywords = {environmental chemistry, matter, megacities, model, monitoring, network, particulate pm10 pollution, quality santiago, system, temuco},
pubstate = {published},
tppubtype = {article}
}

@article{RN128,
title = {Design, Synthesis, Binding and Docking-Based 3d-Qsar Studies of 2-Pyridylbenzimidazoles-a New Family of High Affinity Cb1 Cannabinoid Ligands},
author = { J.A. Mella-Raipan and C.F. Lagos and G. Recabarren-Gajardo and C. Espinosa-Bustos and J. Romero-Parra and H. Pessoa-Mahana and P. Iturriaga-Vasquez and C.D. Pessoa-Mahana},
url = {/brokenurl#<Go to ISI>://WOS:000318020100024},
doi = {10.3390/molecules18043972},
issn = {1420-3049},
year = {2013},
date = {2013-01-01},
journal = {Molecules},
volume = {18},
number = {4},
pages = {3972-4001},
abstract = {A series of novel 2-pyridylbenzimidazole derivatives was rationally designed and synthesized based on our previous studies on benzimidazole 14, a CB1 agonist used as a template for optimization. In the present series, 21 compounds displayed high affinities with K-i values in the nanomolar range. JM-39 (compound 39) was the most active of the series (K-iCB1 = 0.53 nM), while compounds 31 and 44 exhibited similar affinities to WIN 55212-2. CoMFA analysis was performed based on the biological data obtained and resulted in a statistically significant CoMFA model with high predictive value (q(2) = 0.710, r(2) = 0.998, r(pred)(2) = 0.823).},
keywords = {agonists, analogs, analysis, binding, cannabinoid, cb1 comfa derivatives, docking, molecular-field pharmacology, protease receptor, series, system},
pubstate = {published},
tppubtype = {article}
}