2018 |
Ardiles, A; Barrientos, R; Simirgiotis, M J; Borquez, J; Sepulveda, B; Areche, C Gastroprotective Activity of Parastrephia Quadrangularis (Meyen), Cabrera from the Atacama Desert Artículo de revista Molecules, 23 (9), 2018, ISSN: 1420-3049. Resumen | Enlaces | BibTeX | Etiquetas: clerodanes, derivatives, diterpenoids, endemic extracts, gastric gastroprotective, lc-ms/ms, lesions, medicine, mode, natural-products, plants, prostaglandins, rats tremetones, ulcer @article{RN379, title = {Gastroprotective Activity of Parastrephia Quadrangularis (Meyen), Cabrera from the Atacama Desert}, author = { A. Ardiles and R. Barrientos and M.J. Simirgiotis and J. Borquez and B. Sepulveda and C. Areche}, url = {/brokenurl#<Go to ISI>://WOS:000447365100272}, doi = {10.3390/molecules23092361}, issn = {1420-3049}, year = {2018}, date = {2018-01-01}, journal = {Molecules}, volume = {23}, number = {9}, abstract = {Forty-three metabolites including several methoxylated flavonoids, tremetones, and ent-clerodane diterpenes were accurately identified for the first time in the ethanolic extract of P. quadrangularis by means of hyphenated UHPLC-quadrupole Orbitrap mass spectrometry, and seven isolated compounds were tested regarding gastroprotective activity using the HCl/EtOH-induced lesion model in mice. A new tremetone (compound 6) is reported based on spectroscopic evidence. The isolated clerodanes and tremetones showed gastroprotective activity in a mouse model, evidenced by compound 7 (p-coumaroyloxytremetone), which showed the highest gastroprotective activity (76%), which was higher than the control drug lansoprazole (72%). Our findings revealed that several constituents of this plant have gastroprotective activity, and particularly, p-coumaroyloxytremetone could be considered as a lead molecule to explore new gastroprotective agents. This plant is a rich source of biologically active tremetones and terpenoids which can support the ethnobotanical use of the plant.}, keywords = {clerodanes, derivatives, diterpenoids, endemic extracts, gastric gastroprotective, lc-ms/ms, lesions, medicine, mode, natural-products, plants, prostaglandins, rats tremetones, ulcer}, pubstate = {published}, tppubtype = {article} } Forty-three metabolites including several methoxylated flavonoids, tremetones, and ent-clerodane diterpenes were accurately identified for the first time in the ethanolic extract of P. quadrangularis by means of hyphenated UHPLC-quadrupole Orbitrap mass spectrometry, and seven isolated compounds were tested regarding gastroprotective activity using the HCl/EtOH-induced lesion model in mice. A new tremetone (compound 6) is reported based on spectroscopic evidence. The isolated clerodanes and tremetones showed gastroprotective activity in a mouse model, evidenced by compound 7 (p-coumaroyloxytremetone), which showed the highest gastroprotective activity (76%), which was higher than the control drug lansoprazole (72%). Our findings revealed that several constituents of this plant have gastroprotective activity, and particularly, p-coumaroyloxytremetone could be considered as a lead molecule to explore new gastroprotective agents. This plant is a rich source of biologically active tremetones and terpenoids which can support the ethnobotanical use of the plant. |
Fuentes-Barros, G; Castro-Saavedra, S; Liberona, L; Acevedo-Fuentes, W; Tirapegui, C; Mattar, C; Cassels, B K Variation of the Alkaloid Content of Peumus Boldus (Boldo) Artículo de revista Fitoterapia, 127 , pp. 179-185, 2018, ISSN: 0367-326x. Resumen | Enlaces | BibTeX | Etiquetas: activity, alkaloids, antioxidant boldine, boldus, herbal in-vitro, inhibition, leaves, medicine, peumus peumus-boldus, phenanthrene phytochemistry, plants, products, reticuline traditional uhplc-ms/ms @article{RN386, title = {Variation of the Alkaloid Content of Peumus Boldus (Boldo)}, author = { G. Fuentes-Barros and S. Castro-Saavedra and L. Liberona and W. Acevedo-Fuentes and C. Tirapegui and C. Mattar and B.K. Cassels}, url = {/brokenurl#<Go to ISI>://WOS:000437551000027}, doi = {10.1016/j.fitote.2018.02.020}, issn = {0367-326x}, year = {2018}, date = {2018-01-01}, journal = {Fitoterapia}, volume = {127}, pages = {179-185}, abstract = {Eighteen alkaloids were detected in the bark, leaves, wood and roots of Peumus boldus, including traces of secoboldine, N-methylsecoboldine (boldine methine), glaucine and norreticuline, not reported previously as constituents of this species. Using appropriate standards, we quantified thirteen of them by UHPLC-MS/MS. Boldine was dominant in the bark, and laurolitsine in wood and roots. The alkaloid composition of the leaves, determined for 130 individually identified trees, classified by age and sex, was highly variable, where N-methyllaurotetanine, laurotetanine, coclaurine and in some cases isocorydine predominated, but not boldine.}, keywords = {activity, alkaloids, antioxidant boldine, boldus, herbal in-vitro, inhibition, leaves, medicine, peumus peumus-boldus, phenanthrene phytochemistry, plants, products, reticuline traditional uhplc-ms/ms}, pubstate = {published}, tppubtype = {article} } Eighteen alkaloids were detected in the bark, leaves, wood and roots of Peumus boldus, including traces of secoboldine, N-methylsecoboldine (boldine methine), glaucine and norreticuline, not reported previously as constituents of this species. Using appropriate standards, we quantified thirteen of them by UHPLC-MS/MS. Boldine was dominant in the bark, and laurolitsine in wood and roots. The alkaloid composition of the leaves, determined for 130 individually identified trees, classified by age and sex, was highly variable, where N-methyllaurotetanine, laurotetanine, coclaurine and in some cases isocorydine predominated, but not boldine. |
2018 |
Gastroprotective Activity of Parastrephia Quadrangularis (Meyen), Cabrera from the Atacama Desert Artículo de revista Molecules, 23 (9), 2018, ISSN: 1420-3049. |
Variation of the Alkaloid Content of Peumus Boldus (Boldo) Artículo de revista Fitoterapia, 127 , pp. 179-185, 2018, ISSN: 0367-326x. |