2018 |
Fuentes-Barros, G; Castro-Saavedra, S; Liberona, L; Acevedo-Fuentes, W; Tirapegui, C; Mattar, C; Cassels, B K Variation of the Alkaloid Content of Peumus Boldus (Boldo) Artículo de revista Fitoterapia, 127 , pp. 179-185, 2018, ISSN: 0367-326x. Resumen | Enlaces | BibTeX | Etiquetas: activity, alkaloids, antioxidant boldine, boldus, herbal in-vitro, inhibition, leaves, medicine, peumus peumus-boldus, phenanthrene phytochemistry, plants, products, reticuline traditional uhplc-ms/ms @article{RN386, title = {Variation of the Alkaloid Content of Peumus Boldus (Boldo)}, author = { G. Fuentes-Barros and S. Castro-Saavedra and L. Liberona and W. Acevedo-Fuentes and C. Tirapegui and C. Mattar and B.K. Cassels}, url = {/brokenurl#<Go to ISI>://WOS:000437551000027}, doi = {10.1016/j.fitote.2018.02.020}, issn = {0367-326x}, year = {2018}, date = {2018-01-01}, journal = {Fitoterapia}, volume = {127}, pages = {179-185}, abstract = {Eighteen alkaloids were detected in the bark, leaves, wood and roots of Peumus boldus, including traces of secoboldine, N-methylsecoboldine (boldine methine), glaucine and norreticuline, not reported previously as constituents of this species. Using appropriate standards, we quantified thirteen of them by UHPLC-MS/MS. Boldine was dominant in the bark, and laurolitsine in wood and roots. The alkaloid composition of the leaves, determined for 130 individually identified trees, classified by age and sex, was highly variable, where N-methyllaurotetanine, laurotetanine, coclaurine and in some cases isocorydine predominated, but not boldine.}, keywords = {activity, alkaloids, antioxidant boldine, boldus, herbal in-vitro, inhibition, leaves, medicine, peumus peumus-boldus, phenanthrene phytochemistry, plants, products, reticuline traditional uhplc-ms/ms}, pubstate = {published}, tppubtype = {article} } Eighteen alkaloids were detected in the bark, leaves, wood and roots of Peumus boldus, including traces of secoboldine, N-methylsecoboldine (boldine methine), glaucine and norreticuline, not reported previously as constituents of this species. Using appropriate standards, we quantified thirteen of them by UHPLC-MS/MS. Boldine was dominant in the bark, and laurolitsine in wood and roots. The alkaloid composition of the leaves, determined for 130 individually identified trees, classified by age and sex, was highly variable, where N-methyllaurotetanine, laurotetanine, coclaurine and in some cases isocorydine predominated, but not boldine. |
2014 |
Garcia-Beltran, O; Areche, C; Cassels, B K; Suarez, L E C Coumarins Isolated from Esenbeckia Alata (Rutaceae) Artículo de revista Biochemical Systematics and Ecology, 52 , pp. 38-40, 2014, ISSN: 0305-1978. Enlaces | BibTeX | Etiquetas: alata, alkaloids, argentine chemotaxonomy, constituents, derivatives, esenbeckia febrifuga, furocoumarins, grandiflora, limonoids, noncoding plants, regions, rutaceae, terpenes @article{RN184, title = {Coumarins Isolated from Esenbeckia Alata (Rutaceae)}, author = { O. Garcia-Beltran and C. Areche and B.K. Cassels and L.E.C. Suarez}, url = {/brokenurl#<Go to ISI>://WOS:000334138500008}, doi = {10.1016/j.bse.2013.12.011}, issn = {0305-1978}, year = {2014}, date = {2014-01-01}, journal = {Biochemical Systematics and Ecology}, volume = {52}, pages = {38-40}, keywords = {alata, alkaloids, argentine chemotaxonomy, constituents, derivatives, esenbeckia febrifuga, furocoumarins, grandiflora, limonoids, noncoding plants, regions, rutaceae, terpenes}, pubstate = {published}, tppubtype = {article} } |
2013 |
Urra, F A; Cordova-Delgado, M; Pessoa-Mahana, H; Ramirez-Rodriguez, O; Weiss-Lopez, B; Ferreira, J; Araya-Maturana, R Mitochondria: A Promising Target for Anticancer Alkaloids Artículo de revista Current Topics in Medicinal Chemistry, 13 (17), pp. 2171-2183, 2013, ISSN: 1568-0266. Resumen | Enlaces | BibTeX | Etiquetas: alkaloids, apoptosis, cancer capsaicin carbazole caspase-dependent cells, delivery, endoplasmic endoplasmic-reticulum hepatocellular-carcinoma, human induces melanoma-cells microtubule-modulating mitochondria, mouse nucleotide peptide, prostate-cancer reticulum, self-assembling stress, targeting, translocase @article{RN156, title = {Mitochondria: A Promising Target for Anticancer Alkaloids}, author = { F.A. Urra and M. Cordova-Delgado and H. Pessoa-Mahana and O. Ramirez-Rodriguez and B. Weiss-Lopez and J. Ferreira and R. Araya-Maturana}, url = {/brokenurl#<Go to ISI>://WOS:000324801300007}, issn = {1568-0266}, year = {2013}, date = {2013-01-01}, journal = {Current Topics in Medicinal Chemistry}, volume = {13}, number = {17}, pages = {2171-2183}, abstract = {A great number of alkaloids exhibit high potential in cancer research. Some of them are anticancer drugs with well-defined clinical uses, exerting their action on microtubules dynamics or DNA replication and topology. On the other hand, mitochondria have been recognized as an essential organelle in the establishment of tumor characteristics, especially the resistance to cell death, high proliferative capacity and adaptation to unfavorable cellular environment. Interestingly, many alkaloids exert their anticancer activities affecting selectively some functions of the tumor mitochondria by 1) modulating OXPHOS and ADP/ATP transport, 2) increasing ROS levels and mitochondrial potential dissipation by crosstalk between endoplasmic reticulum (ER) and mitochondria, 3) inducing mitochondria-dependent apoptosis and autophagy, 4) inhibiting mitochondrial metabolic pathways and 5) by alteration of the morphology and biogenesis of this organelle. These antecedents show the relevance of developing research about the effects of alkaloids on functions controlled by tumor mitochondria, offering an attractive target for the design of new alkaloid derivatives, considering organelle-specific delivery strategies. This review describes mitochondria as a central component in the anticancer action of a set of alkaloids, in a way to illustrate the importance of this organelle in medicinal chemistry.}, keywords = {alkaloids, apoptosis, cancer capsaicin carbazole caspase-dependent cells, delivery, endoplasmic endoplasmic-reticulum hepatocellular-carcinoma, human induces melanoma-cells microtubule-modulating mitochondria, mouse nucleotide peptide, prostate-cancer reticulum, self-assembling stress, targeting, translocase}, pubstate = {published}, tppubtype = {article} } A great number of alkaloids exhibit high potential in cancer research. Some of them are anticancer drugs with well-defined clinical uses, exerting their action on microtubules dynamics or DNA replication and topology. On the other hand, mitochondria have been recognized as an essential organelle in the establishment of tumor characteristics, especially the resistance to cell death, high proliferative capacity and adaptation to unfavorable cellular environment. Interestingly, many alkaloids exert their anticancer activities affecting selectively some functions of the tumor mitochondria by 1) modulating OXPHOS and ADP/ATP transport, 2) increasing ROS levels and mitochondrial potential dissipation by crosstalk between endoplasmic reticulum (ER) and mitochondria, 3) inducing mitochondria-dependent apoptosis and autophagy, 4) inhibiting mitochondrial metabolic pathways and 5) by alteration of the morphology and biogenesis of this organelle. These antecedents show the relevance of developing research about the effects of alkaloids on functions controlled by tumor mitochondria, offering an attractive target for the design of new alkaloid derivatives, considering organelle-specific delivery strategies. This review describes mitochondria as a central component in the anticancer action of a set of alkaloids, in a way to illustrate the importance of this organelle in medicinal chemistry. |
2018 |
Variation of the Alkaloid Content of Peumus Boldus (Boldo) Artículo de revista Fitoterapia, 127 , pp. 179-185, 2018, ISSN: 0367-326x. |
2014 |
Coumarins Isolated from Esenbeckia Alata (Rutaceae) Artículo de revista Biochemical Systematics and Ecology, 52 , pp. 38-40, 2014, ISSN: 0305-1978. |
2013 |
Mitochondria: A Promising Target for Anticancer Alkaloids Artículo de revista Current Topics in Medicinal Chemistry, 13 (17), pp. 2171-2183, 2013, ISSN: 1568-0266. |