2016 |
Duffau, B; Camargo, C; Kogan, M; Fuentes, E; Cassels, B K Analysis of 25 C Nbome in Seized Blotters by Hptlc and Gc-Ms Artículo de revista Journal of Chromatographic Science, 54 (7), pp. 1153-1158, 2016, ISSN: 0021-9665. Resumen | Enlaces | BibTeX | Etiquetas: guide uncertainty, validation @article{RN293, title = {Analysis of 25 C Nbome in Seized Blotters by Hptlc and Gc-Ms}, author = { B. Duffau and C. Camargo and M. Kogan and E. Fuentes and B.K. Cassels}, url = {/brokenurl#<Go to ISI>://WOS:000389138700012}, doi = {10.1093/chromsci/bmw095}, issn = {0021-9665}, year = {2016}, date = {2016-01-01}, journal = {Journal of Chromatographic Science}, volume = {54}, number = {7}, pages = {1153-1158}, abstract = {Use of unauthorized synthetic drugs is a serious, forensic, regulatory and public health issue. In this scenario, consumption of drug-impregnated blotters is very frequent. For decades, blotters have been generally impregnated with the potent hallucinogen known as lysergic acid diethylamide (LSD); however, since 2013 blotter stamps with N-2 methoxybenzyl-substituted phenylethylamine hallucinogen designated as "NBOMes" have been seized in Chile. To address this issue with readily accessible laboratory equipment, we have developed and validated a new HPTLC method for the identification and quantitation of 25-C-NBOMe in seized blotters and its confirmation by GC-MS. The proposed method was validated according to SWGTOX recommendations and is suitable for routine analysis of seized blotters containing 25-C-NBOMe. With the validated method, we analyzed 15 real samples, in all cases finding 25-C-NBOMe in a wide dosage range (701.0-1943.5 mu g per blotter). In this situation, we can assume that NBOMes are replacing LSD as the main hallucinogenic drug consumed in blotters in Chile.}, keywords = {guide uncertainty, validation}, pubstate = {published}, tppubtype = {article} } Use of unauthorized synthetic drugs is a serious, forensic, regulatory and public health issue. In this scenario, consumption of drug-impregnated blotters is very frequent. For decades, blotters have been generally impregnated with the potent hallucinogen known as lysergic acid diethylamide (LSD); however, since 2013 blotter stamps with N-2 methoxybenzyl-substituted phenylethylamine hallucinogen designated as "NBOMes" have been seized in Chile. To address this issue with readily accessible laboratory equipment, we have developed and validated a new HPTLC method for the identification and quantitation of 25-C-NBOMe in seized blotters and its confirmation by GC-MS. The proposed method was validated according to SWGTOX recommendations and is suitable for routine analysis of seized blotters containing 25-C-NBOMe. With the validated method, we analyzed 15 real samples, in all cases finding 25-C-NBOMe in a wide dosage range (701.0-1943.5 mu g per blotter). In this situation, we can assume that NBOMes are replacing LSD as the main hallucinogenic drug consumed in blotters in Chile. |
2016 |
Analysis of 25 C Nbome in Seized Blotters by Hptlc and Gc-Ms Artículo de revista Journal of Chromatographic Science, 54 (7), pp. 1153-1158, 2016, ISSN: 0021-9665. |