Publicaciones 2011-2020

@article{RN199,
title = {Gamma-Cyclodextrin/Alkylthiol Inclusion Compounds Crystals as Substrates for the Formation and Immobilization of Gold Nanoparticles Produced by Magnetron Sputtering},
author = { M. Diaz and N. Silva and N. Yutronic and E. Pena and B. Chornik and P. Jara},
url = {/brokenurl#<Go to ISI>://WOS:000341814600017},
doi = {10.1007/s10847-014-0417-3},
issn = {1388-3127},
year = {2014},
date = {2014-01-01},
journal = {Journal of Inclusion Phenomena and Macrocyclic Chemistry},
volume = {80},
number = {1-2},
pages = {133-138},
abstract = {In this work, we report the nanodecoration of microcrystals of inclusion compound (IC) of gamma-cyclodextrin (gamma-CD) that contain octanethiol, decanethiol and dodecanethiol. Crystals of these ICs provide a suitable environment for nucleation, growth and immobilization of gold nanoparticles that were obtained by the magnetron sputtering technique. The use of gamma-CD IC substrates with a specific surface morphology (i.e., the functional group of the guest molecule faces outward preferentially from a crystal plane) is an efficient method for the preparation of AuNPs with low size dispersion, which is due to the high affinity between the functional group of the surfactant alkylthiol guest with the metal nanoparticles.},
keywords = {complexes compounds, cyclodextrin, gold inclusion magnetron nanoparticles, sputtering, stability},
pubstate = {published},
tppubtype = {article}
}

@article{RN86,
title = {Theoretical Study of the Local Reactivity of Electrophiles of the Type Mpr (3) (+) (M = Cu, Ag, Au ;R = -H, -Me, -Ph)},
author = { D. Burgos and C. Olea-Azar and F. Mendizabal},
url = {/brokenurl#<Go to ISI>://WOS:000303541900031},
doi = {10.1007/s00894-011-1213-2},
issn = {1610-2940},
year = {2012},
date = {2012-01-01},
journal = {Journal of Molecular Modeling},
volume = {18},
number = {5},
pages = {2021-2029},
abstract = {Reactivity prediction in the series of MPR (3) (+) fragments ( M = Au, Ag, Cu; R = -H, -Me, -Ph) has been achieved at the ab initio (HF and MP2) and density functional theory (B3LYP and PBE) levels. We have used global and local descriptors based on conceptual DFT such as hardness, Fukui function and electrophilicity index. For all methods and fragments, we have found an equal trend in reactivity using both the global and local electrophilicity index: QR-AuPR (3) (+) > CuPR (3) (+) a parts per thousand aEuro parts per thousand AgPR (3) (+) > NR-AuPR (3) (+) . It is also found that the electrophilicity power decreases as the volume of R increases.},
keywords = {approximation, chemistry complexes, effects, electrophile fragments, gold, hardness, quasi-relativistic reactivity, stability},
pubstate = {published},
tppubtype = {article}
}

@article{RN36h,
title = {A Preparative Method for the Purification of Isopenicillin N from Genetically Blocked Acremonium Chrysogenum Strain Td189: Studies on the Degradation Kinetics and Storage Conditions},
author = { I. Vaca and J. Casqueiro and R.V. Ullan and A. Rumbero and R. Chavez and J.F. Martin},
url = {/brokenurl#<Go to ISI>://WOS:000292090800006},
doi = {10.1038/ja.2011.30},
issn = {0021-8820},
year = {2011},
date = {2011-01-01},
journal = {Journal of Antibiotics},
volume = {64},
number = {6},
pages = {447-451},
abstract = {A protocol for preparative isopenicillin N (IPN) purification, a highly interesting and hitherto unavailable intermediate of the penicillin and cephalosporin biosynthetic pathway due to its high unstability, is described. Culture broths of Acremonium chrysogenum TD189, a strain blocked in cephalosporin biosynthesis that accumulates this metabolite, were treated with acetone and filtered though charcoal and a hydrophobic resin in a single step as tandem columns. The cleared broth was then lyophilized and passed though a Sephadex G-25 column. The last step was the purification to homogeneity of IPN in a semipreparative HPLC equipment and, optionally, a desalting step by Sephadex G-10 column. Once purified, a complete analysis of the stability of the compound and the conditions for its long-term storage was carried out. Our results suggest a first-order model for IPN decomposition for all the pH and temperature analyzed. IPN is more stable at neutral pH, and once lyophilized, can be stored under vacuum and -75 degrees C with a half-life of 770 days. The Journal of Antibiotics (2011); published online 27 April 2011},
keywords = {biosynthesis, cephalosporin-c, chrysogenum, conversion, hplc, isopenicillin liquid-chromatography n, natural-products, penicillium-chrysogenum, purification, stability, storage, system temperature},
pubstate = {published},
tppubtype = {article}
}