2014 |
Garcia-Beltran, O; Yanez, O; Caballero, J; Galdámez, A; Mena, N; Nunez, M; Cassels, B K Synthesis of Coumarin Derivatives as Fluorescent Probes for Membrane and Cell Dynamics Studies Artículo de revista European Journal of Medicinal Chemistry, 76 , pp. 79-86, 2014, ISSN: 0223-5234. Resumen | Enlaces | BibTeX | Etiquetas: biological-membranes, carboxylic-acids, cell coumarins, crystal-structure, decarboxylation depth, dynamics, energy-transfer, hydrogen-bond, membranes, model, molecular molecular-dynamics, probes, proteins, resonance @article{RN192, title = {Synthesis of Coumarin Derivatives as Fluorescent Probes for Membrane and Cell Dynamics Studies}, author = { O. Garcia-Beltran and O. Yanez and J. Caballero and A. Gald\'{a}mez and N. Mena and M. Nunez and B.K. Cassels}, url = {/brokenurl#<Go to ISI>://WOS:000335487400009}, doi = {10.1016/j.ejmech.2014.02.016}, issn = {0223-5234}, year = {2014}, date = {2014-01-01}, journal = {European Journal of Medicinal Chemistry}, volume = {76}, pages = {79-86}, publisher = {2014 Elsevier Masson SAS.}, abstract = {Three coumarin-derived fluorescent probes, 3-acetyl-7-[(6-bromohexyl)oxy]-2H-chromen-2-one (FM1), 7-[(6-bromohexyl)oxy]-4-methyl-2H-chromen-2-one (FM2) and ethyl 2-7-[(6-bromohexyl)oxy]-2-oxo-2H-chromen-4-ylacetate (FM3), are described, with their photophysical constants. The compounds were tested in preliminary studies employing epifluorescence microscopy demonstrating that they allow the imaging of human neuroblastoma SH-SY5Y cell membranes. The structure of FM3 was confirmed by X-ray crystallographic analysis. Molecular dynamics (MD) simulations were used to characterize the localization and interactions of the studied compounds with a lipid bilayer model of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC).}, keywords = {biological-membranes, carboxylic-acids, cell coumarins, crystal-structure, decarboxylation depth, dynamics, energy-transfer, hydrogen-bond, membranes, model, molecular molecular-dynamics, probes, proteins, resonance}, pubstate = {published}, tppubtype = {article} } Three coumarin-derived fluorescent probes, 3-acetyl-7-[(6-bromohexyl)oxy]-2H-chromen-2-one (FM1), 7-[(6-bromohexyl)oxy]-4-methyl-2H-chromen-2-one (FM2) and ethyl 2-7-[(6-bromohexyl)oxy]-2-oxo-2H-chromen-4-ylacetate (FM3), are described, with their photophysical constants. The compounds were tested in preliminary studies employing epifluorescence microscopy demonstrating that they allow the imaging of human neuroblastoma SH-SY5Y cell membranes. The structure of FM3 was confirmed by X-ray crystallographic analysis. Molecular dynamics (MD) simulations were used to characterize the localization and interactions of the studied compounds with a lipid bilayer model of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC). |
Aguayo, T; Araya, M C; Icaza, T M; Campos-Vallette, M A Vibrational Approach for the Study of Historical Weighted and Dyed Silks Artículo de revista Journal of Molecular Structure, 1075 , pp. 471-478, 2014, ISSN: 0022-2860. Resumen | Enlaces | BibTeX | Etiquetas: atr, bombyx bombyx-mori, conformation, conservation, degradation, deterioration, enhanced infrared-spectroscopy, inks, mori, proteins, raman, raman-scattering, silk, textiles weighted @article{RN212, title = {A Vibrational Approach for the Study of Historical Weighted and Dyed Silks}, author = { T. Aguayo and M.C. Araya and T.M. Icaza and M. Campos-Vallette}, url = {/brokenurl#<Go to ISI>://WOS:000342254500056}, doi = {10.1016/j.molstruc.2014.07.016}, issn = {0022-2860}, year = {2014}, date = {2014-01-01}, journal = {Journal of Molecular Structure}, volume = {1075}, pages = {471-478}, publisher = {2014 Elsevier B.V.}, abstract = {Samples from six different historic silk objects were studied with the Raman and ATR-IR vibrational techniques. A set of degummed and weighted silks was prepared in order to recognize the vibrational signature associated with the processes used. The spectral information allowed the identification of the weighting process and the dyes used in some of the cases. The different spectra also allowed infer about the deterioration observed in the samples. The silk fibroin displays slight conformational modifications by the weighting process. The degumming process seems to have no chemical effect on the fibroin stability.}, keywords = {atr, bombyx bombyx-mori, conformation, conservation, degradation, deterioration, enhanced infrared-spectroscopy, inks, mori, proteins, raman, raman-scattering, silk, textiles weighted}, pubstate = {published}, tppubtype = {article} } Samples from six different historic silk objects were studied with the Raman and ATR-IR vibrational techniques. A set of degummed and weighted silks was prepared in order to recognize the vibrational signature associated with the processes used. The spectral information allowed the identification of the weighting process and the dyes used in some of the cases. The different spectra also allowed infer about the deterioration observed in the samples. The silk fibroin displays slight conformational modifications by the weighting process. The degumming process seems to have no chemical effect on the fibroin stability. |
2014 |
Synthesis of Coumarin Derivatives as Fluorescent Probes for Membrane and Cell Dynamics Studies Artículo de revista European Journal of Medicinal Chemistry, 76 , pp. 79-86, 2014, ISSN: 0223-5234. |
A Vibrational Approach for the Study of Historical Weighted and Dyed Silks Artículo de revista Journal of Molecular Structure, 1075 , pp. 471-478, 2014, ISSN: 0022-2860. |