2014 |
Garcia-Beltran, O; Cassels, B K; Perez, C; Mena, N; Nunez, M; Martinez, N P; Pavez, P; Aliaga, M E Coumarin-Based Fluorescent Probes for Dual Recognition of Copper(Ii) and Iron(Iii) Ions and Their Application in Bio-Imaging Artículo de revista Sensors, 14 (1), pp. 1358-1371, 2014, ISSN: 1424-8220. Resumen | Enlaces | BibTeX | Etiquetas: bio-imaging, chemosensor, coumarin-based cu2+ cu2+, design, fe3+ fluorescence ion, probes, sensor sensors, turn-off @article{RN194, title = {Coumarin-Based Fluorescent Probes for Dual Recognition of Copper(Ii) and Iron(Iii) Ions and Their Application in Bio-Imaging}, author = { O. Garcia-Beltran and B.K. Cassels and C. Perez and N. Mena and M. Nunez and N.P. Martinez and P. Pavez and M.E. Aliaga}, url = {/brokenurl#<Go to ISI>://WOS:000336039100075}, doi = {10.3390/s140101358}, issn = {1424-8220}, year = {2014}, date = {2014-01-01}, journal = {Sensors}, volume = {14}, number = {1}, pages = {1358-1371}, abstract = {Two new coumarin-based "turn-off" fluorescent probes, (E)-3-((3,4-dihydroxybenzylidene)amino)-7-hydroxy-2H-chromen-2-one (BS1) and (E)-3-((2,4-dihydroxybenzylidene)amino)-7-hydroxy-2H-chromen-2-one (BS2), were synthesized and their detection of copper(II) and iron(III) ions was studied. Results show that both compounds are highly selective for Cu2+ and Fe3+ ions over other metal ions. However, BS2 is detected directly, while detection of BS1 involves a hydrolysis reaction to regenerate 3-amino-7-hydroxycoumarin (3) and 3,4-dihydroxybenzaldehyde, of which 3 is able to react with copper(II) or iron(III) ions. The interaction between the tested compounds and copper or iron ions is associated with a large fluorescence decrease, showing detection limits of ca. 10(-5) M. Preliminary studies employing epifluorescence microscopy demonstrate that Cu2+ and Fe3+ ions can be imaged in human neuroblastoma SH-SY5Y cells treated with the tested probes.}, keywords = {bio-imaging, chemosensor, coumarin-based cu2+ cu2+, design, fe3+ fluorescence ion, probes, sensor sensors, turn-off}, pubstate = {published}, tppubtype = {article} } Two new coumarin-based "turn-off" fluorescent probes, (E)-3-((3,4-dihydroxybenzylidene)amino)-7-hydroxy-2H-chromen-2-one (BS1) and (E)-3-((2,4-dihydroxybenzylidene)amino)-7-hydroxy-2H-chromen-2-one (BS2), were synthesized and their detection of copper(II) and iron(III) ions was studied. Results show that both compounds are highly selective for Cu2+ and Fe3+ ions over other metal ions. However, BS2 is detected directly, while detection of BS1 involves a hydrolysis reaction to regenerate 3-amino-7-hydroxycoumarin (3) and 3,4-dihydroxybenzaldehyde, of which 3 is able to react with copper(II) or iron(III) ions. The interaction between the tested compounds and copper or iron ions is associated with a large fluorescence decrease, showing detection limits of ca. 10(-5) M. Preliminary studies employing epifluorescence microscopy demonstrate that Cu2+ and Fe3+ ions can be imaged in human neuroblastoma SH-SY5Y cells treated with the tested probes. |
2013 |
Garcia-Beltran, O; Mena, N; Yanez, O; Caballero, J; Vargas, V; Nunez, M; Cassels, B K Design, Synthesis and Cellular Dynamics Studies in Membranes of a New Coumarin-Based "Turn-Off" Fluorescent Probe Selective for Fe2+ Artículo de revista European Journal of Medicinal Chemistry, 67 , pp. 60-63, 2013, ISSN: 0223-5234. Resumen | Enlaces | BibTeX | Etiquetas: cells, chelatable chelators, chemosensor, deficiency, dynamics, fe2+ fe3+ fluorescent ion, iron, labile molecular probes, sensor, turn-off @article{RN125, title = {Design, Synthesis and Cellular Dynamics Studies in Membranes of a New Coumarin-Based "Turn-Off" Fluorescent Probe Selective for Fe2+}, author = { O. Garcia-Beltran and N. Mena and O. Yanez and J. Caballero and V. Vargas and M. Nunez and B.K. Cassels}, url = {/brokenurl#<Go to ISI>://WOS:000325121800007}, doi = {10.1016/j.ejmech.2013.06.022}, issn = {0223-5234}, year = {2013}, date = {2013-01-01}, journal = {European Journal of Medicinal Chemistry}, volume = {67}, pages = {60-63}, publisher = {2013 Elsevier Masson SAS.}, abstract = {A new coumarin-based 'turn-off' fluorescent probe, 7-(diethylamino)-N-(1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl)-2-oxo-2H-chromene-3-carboxamide (AGD) was synthesized. This compound is highly selective for ferrous ions (Fe2+) and can reversibly detect them in aqueous medium. The probe localizes to the cell membrane in living cells, where it can detect changes in Fe2+ concentration. Molecular dynamics (MD) simulations indicate that AGD interacts with the lipid bilayer at the level of the glycerol moieties.}, keywords = {cells, chelatable chelators, chemosensor, deficiency, dynamics, fe2+ fe3+ fluorescent ion, iron, labile molecular probes, sensor, turn-off}, pubstate = {published}, tppubtype = {article} } A new coumarin-based 'turn-off' fluorescent probe, 7-(diethylamino)-N-(1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl)-2-oxo-2H-chromene-3-carboxamide (AGD) was synthesized. This compound is highly selective for ferrous ions (Fe2+) and can reversibly detect them in aqueous medium. The probe localizes to the cell membrane in living cells, where it can detect changes in Fe2+ concentration. Molecular dynamics (MD) simulations indicate that AGD interacts with the lipid bilayer at the level of the glycerol moieties. |
2014 |
Coumarin-Based Fluorescent Probes for Dual Recognition of Copper(Ii) and Iron(Iii) Ions and Their Application in Bio-Imaging Artículo de revista Sensors, 14 (1), pp. 1358-1371, 2014, ISSN: 1424-8220. |
2013 |
Design, Synthesis and Cellular Dynamics Studies in Membranes of a New Coumarin-Based "Turn-Off" Fluorescent Probe Selective for Fe2+ Artículo de revista European Journal of Medicinal Chemistry, 67 , pp. 60-63, 2013, ISSN: 0223-5234. |