Publicaciones 2011-2020

@article{RN339,
title = {Heterotrimeric G Protein Alpha Subunit Controls Growth, Stress Response, Extracellular Protease Activity, and Cyclopiazonic Acid Production in Penicillium Camemberti},
author = { R.O. Garcia-Rico and C. Gil-Duran and J.F. Rojas-Aedo and I. Vaca and L. Figueroa and G. Levican and R. Chavez},
url = {/brokenurl#<Go to ISI>://WOS:000419930600002},
doi = {10.1016/j.funbio.2017.05.007},
issn = {1878-6146},
year = {2017},
date = {2017-01-01},
journal = {Fungal Biology},
volume = {121},
number = {9},
pages = {754-762},
publisher = {2017 British Mycological Society. Published by Elsevier Ltd.},
abstract = {The fungus Penicillium camemberti is widely used in the ripening of various bloomy-rind cheeses. Several properties of P. camemberti are important in cheese ripening, including conidiation, growth and enzyme production, among others. However, the production of mycotoxins such as cyclopiazonic acid during the ripening process by P. camemberti has raised concerns among consumers that demand food with minimal contamination. Here we show that overexpressing an alpha-subunit from the subgroup I of the heterotrimeric G protein (G alpha i) influences several of these processes: it negatively affects growth in a media dependent manner, triggers conidial germination, reduces the rate of sporulation, affects thermal and osmotic stress resistance, and also extracellular protease and cyclopiazonic acid production. Our results contribute to understanding the biological determinants underlying these biological processes in the economically important fungus P. camemberti.},
keywords = {alpha-subunit, aspergillus-nidulans, expression, filamentous fungus, g-beta, gene, geotrichum-candidum, growth, metabolism, micotoxin, mycotoxin pathogenicity, pcr, production, proteases, real-time reproduction resistance, secondary stress vegetative},
pubstate = {published},
tppubtype = {article}
}

@article{RN157,
title = {On the Mechanism of Biological Activity of Hydroquinone Derivatives That Inhibit Tumor Cell Respiration. A Theoretical Study},
author = { J. Soto-Delgado and V.E. Bahamonde-Padilla and R. Araya-Maturana and B. Weiss-Lopez},
url = {/brokenurl#<Go to ISI>://WOS:000319102800015},
doi = {10.1016/j.comptc.2013.03.007},
issn = {2210-271x},
year = {2013},
date = {2013-01-01},
journal = {Computational and Theoretical Chemistry},
volume = {1013},
pages = {97-101},
publisher = {2013 Elsevier B.V.},
abstract = {A simple mechanism to understand the biological activity of a series of hydroquinone derivatives is proposed. To validate this proposition Gibbs free energies of formation of the different species involved were calculated. The calculations were performed using density functional theory (DFT) at B3LYP/6-31++G(2df,p) level of theory, including solvation effect. The results show that two important variables to examine are the equilibrium phenol-phenoxide and the solvation energy of neutral species, since the balance between both variables affects the capability of the molecules to cross membranes. Once the molecule crossed the membrane, the formation of radical species shows a qualitative correlation with the magnitude of IC50 values. This provides a reasonable criterion to search for more efficient anticancer drug.},
keywords = {alpha-tocopheryl antioxidant, antitumoral calculation, cancer, cell dft drugs, generation, growth, hydroquinone, in-vivo, mechanism, mitochondria, oxidation, pathways respiration, semiquinone, succinate, targeting tumor},
pubstate = {published},
tppubtype = {article}
}