Publicaciones 2011-2020

@article{RN405,
title = {Porous Nanogold/Polyurethane Scaffolds with Improved Antibiofilm, Mechanical, and Thermal Properties and with Reduced Effects on Cell Viability: A Suitable Material for Soft Tissue Applications},
author = { L. Tamayo and D. Acuna and A. Riveros and M.J. Kogan and M. Azocar and M. Paez and M. Leal and M. Urz\'{u}a and E. Cerda},
url = {/brokenurl#<Go to ISI>://WOS:000431150900013},
doi = {10.1021/acsami.8b02347},
issn = {1944-8244},
year = {2018},
date = {2018-01-01},
journal = {Acs Applied Materials & Interfaces},
volume = {10},
number = {16},
pages = {13361-13372},
abstract = {The use of implants carries on a series of problems, among them infections, poor biocompatibility, high levels of cytotoxicity, and significant mechanical differences between implants and host organs that promote stress shielding effects. These problems indicate that the materials used to make implants must meet essential requirements and high standards for implantations to be successful. In this work, we present the synthesis, characterization and evaluation of the antibiofilm, mechanical, and thermal properties, and cytotoxic effect of a nanocomposite-based scaffold on polyurethane (PU) and gold nanoparticles (AuNPs) for soft tissue applications. The effect of the quantity of AuNPs on the antibacterial activity of nanocomposite scaffolds was evaluated against Staphylococcus epidermidis and Klebsiella spp., with a resulting 99.99% inhibition of both bacteria using a small quantity of nanoparticles. Cytotoxicity was evaluated with the T10 1/2 test against fibroblast cells. The results demonstrated that porous nanogold/PU scaffolds have no toxic effects on fibroblast cells to the 5 day exposition. With respect to mechanical properties, stress strain curves showed that the compressive modulus and yield strength of PU scaffolds were significantly enhanced by AuNPs (by at least 10 times). This is due to changes in the arrangement of hard segments of PU, which increase the stiffness of the polymer. Thermogravimetric analysis showed that the degradation onset temperature rises with an increase in the quantity of AuNPs. These properties and characteristics demonstrate that porous nanogold/PU scaffolds are suitable material for use in soft tissue implants.},
keywords = {antibiofilm, applications, bacterial biomaterials, biomedical gold in-vitro, leaching mechanical molecular-weight, nanocomposites nanoparticles, non-cytotoxic, particle-size, phase-separation, polyurethane, porous properties, scaffolds, techniques, thermoplastic},
pubstate = {published},
tppubtype = {article}
}

@article{RN352,
title = {Construction of 6-Thioguanine and 6-Mercaptopurine Carriers Based on Beta Cyclodextrins and Gold Nanoparticles},
author = { R. Sierpe and M. Noyong and U. Simon and D. Aguayo and J. Huerta and M.J. Kogan and N. Yutronic},
url = {/brokenurl#<Go to ISI>://WOS:000411876200003},
doi = {10.1016/j.carbpol.2017.08.102},
issn = {0144-8617},
year = {2017},
date = {2017-01-01},
journal = {Carbohydrate Polymers},
volume = {177},
pages = {22-31},
abstract = {As a novel strategy to overcome some of the therapeutic disadvantages of 6-thioguanine (TG) and 6-mercaptopurine (MP), we propose the inclusion of these drugs in beta cyclodextrin (beta CD) to form the complexes beta CD-TG and beta CD-MP, followed by subsequent interaction with gold nanoparticles (AuNPs), generating the ternary systems: beta CD-TG-AuNPs and beta CD-MP-AuNPs. This modification increased their solubility and improved their stability, betting by a site-specific transport due to their nanometric dimensions, among other advantages., The formation of the complexes was confirmed using powder X-ray diffraction, thermogravimetric analysis and one and two-dimensional NMR. A theoretical study using DFT and molecular modelling was conducted to obtain the more stable tautomeric species of TG and MP in solution and confirm the proposed inclusion geometries. The deposition of AuNPs onto beta CD-TG and beta CD-MP via sputtering was confirmed by UV-vis spectroscopy. Subsequently, the ternary systems were characterized by TEM, FE-SEM and EDX to directly observe the deposited AuNPs and evaluate their sizes, size dispersion, and composition. Finally, the in vitro permeability of the ternary systems was studied using parallel artificial membrane permeability assay (PAMPA).},
keywords = {anisotropic antineoplastic, applications, cancer, complex, complexes, cytotoxicity delivery, dielectrics, drug drug-delivery, enhanced inclusion ionic-solutions, nanotechnology, permeability, pharmaceutical photothermal solid-state, sputtering, therapy},
pubstate = {published},
tppubtype = {article}
}

@article{RN249,
title = {Gold Nanoparticles Interacting with Beta-Cyclodextrin-Phenylethylamine Inclusion Complex: A Ternary System for Photothermal Drug Release},
author = { R. Sierpe and E. Lang and P. Jara and A.R. Guerrero and B. Chornik and M.J. Kogan and N. Yutronic},
url = {/brokenurl#<Go to ISI>://WOS:000358558300010},
doi = {10.1021/acsami.5b00186},
issn = {1944-8244},
year = {2015},
date = {2015-01-01},
journal = {Acs Applied Materials & Interfaces},
volume = {7},
number = {28},
pages = {15177-15188},
abstract = {We report the synthesis of a 1:1 beta-cydodextrin-phenylethylamine (beta CD-PhEA) inclusion complex (IC) and the adhesion of gold nanoparticles (AuNPs) onto micro crystals of this complex, which forms a ternary system. The formation of the IC was confirmed by powder X-ray diffraction and NMR analyses (H-1 and ROESY). The stability constant of the IC (760 M-1) was determined using the phase solubility method. The adhesion of AuNPs was obtained using the magnetron sputtering technique, and the presence of AuNPs was confirmed using UV-vis spectroscopy (surface plasmon resonance effect), which showed. an absorbance at 533 nm. The powder X-ray diffractograms of beta CD-PhEA were similar to those of the crystals decorated with AuNPs. A comparison of the one- and two-dimensional NMR spectra of the IC with and without AuNPs suggests partial displacement of the guest to the outside of the beta CD due to attraction toward AuNPs, a characteristic tropism effect. The size, morphology, and distribution of the AuNPs were analyzed using TEM and SEM. The average size of the AuNPs was 14 nm. Changes in the IR and Raman spectra were attributed to the formation of the complex and to the specific interactions of this group with the AuNPs. Laser irradiation assays show that the ternary system beta CD-PhEA-AuNPs in solution enables the release of the guest.},
keywords = {applications, beta-cyclodextrin, biomedical brain complex, delivery, effect, enhanced gold inclusion laser-ablation, magnetron nanoparticles, permeability, phenylethylamine, photothermal plasmon resonance, retention, silver size, sputtering, surface},
pubstate = {published},
tppubtype = {article}
}