2017 |
Sierpe, R; Noyong, M; Simon, U; Aguayo, D; Huerta, J; Kogan, M J; Yutronic, N Construction of 6-Thioguanine and 6-Mercaptopurine Carriers Based on Beta Cyclodextrins and Gold Nanoparticles Artículo de revista Carbohydrate Polymers, 177 , pp. 22-31, 2017, ISSN: 0144-8617. Resumen | Enlaces | BibTeX | Etiquetas: anisotropic antineoplastic, applications, cancer, complex, complexes, cytotoxicity delivery, dielectrics, drug drug-delivery, enhanced inclusion ionic-solutions, nanotechnology, permeability, pharmaceutical photothermal solid-state, sputtering, therapy @article{RN352, title = {Construction of 6-Thioguanine and 6-Mercaptopurine Carriers Based on Beta Cyclodextrins and Gold Nanoparticles}, author = { R. Sierpe and M. Noyong and U. Simon and D. Aguayo and J. Huerta and M.J. Kogan and N. Yutronic}, url = {/brokenurl#<Go to ISI>://WOS:000411876200003}, doi = {10.1016/j.carbpol.2017.08.102}, issn = {0144-8617}, year = {2017}, date = {2017-01-01}, journal = {Carbohydrate Polymers}, volume = {177}, pages = {22-31}, abstract = {As a novel strategy to overcome some of the therapeutic disadvantages of 6-thioguanine (TG) and 6-mercaptopurine (MP), we propose the inclusion of these drugs in beta cyclodextrin (beta CD) to form the complexes beta CD-TG and beta CD-MP, followed by subsequent interaction with gold nanoparticles (AuNPs), generating the ternary systems: beta CD-TG-AuNPs and beta CD-MP-AuNPs. This modification increased their solubility and improved their stability, betting by a site-specific transport due to their nanometric dimensions, among other advantages., The formation of the complexes was confirmed using powder X-ray diffraction, thermogravimetric analysis and one and two-dimensional NMR. A theoretical study using DFT and molecular modelling was conducted to obtain the more stable tautomeric species of TG and MP in solution and confirm the proposed inclusion geometries. The deposition of AuNPs onto beta CD-TG and beta CD-MP via sputtering was confirmed by UV-vis spectroscopy. Subsequently, the ternary systems were characterized by TEM, FE-SEM and EDX to directly observe the deposited AuNPs and evaluate their sizes, size dispersion, and composition. Finally, the in vitro permeability of the ternary systems was studied using parallel artificial membrane permeability assay (PAMPA).}, keywords = {anisotropic antineoplastic, applications, cancer, complex, complexes, cytotoxicity delivery, dielectrics, drug drug-delivery, enhanced inclusion ionic-solutions, nanotechnology, permeability, pharmaceutical photothermal solid-state, sputtering, therapy}, pubstate = {published}, tppubtype = {article} } As a novel strategy to overcome some of the therapeutic disadvantages of 6-thioguanine (TG) and 6-mercaptopurine (MP), we propose the inclusion of these drugs in beta cyclodextrin (beta CD) to form the complexes beta CD-TG and beta CD-MP, followed by subsequent interaction with gold nanoparticles (AuNPs), generating the ternary systems: beta CD-TG-AuNPs and beta CD-MP-AuNPs. This modification increased their solubility and improved their stability, betting by a site-specific transport due to their nanometric dimensions, among other advantages., The formation of the complexes was confirmed using powder X-ray diffraction, thermogravimetric analysis and one and two-dimensional NMR. A theoretical study using DFT and molecular modelling was conducted to obtain the more stable tautomeric species of TG and MP in solution and confirm the proposed inclusion geometries. The deposition of AuNPs onto beta CD-TG and beta CD-MP via sputtering was confirmed by UV-vis spectroscopy. Subsequently, the ternary systems were characterized by TEM, FE-SEM and EDX to directly observe the deposited AuNPs and evaluate their sizes, size dispersion, and composition. Finally, the in vitro permeability of the ternary systems was studied using parallel artificial membrane permeability assay (PAMPA). |
2015 |
Sierpe, R; Lang, E; Jara, P; Guerrero, A R; Chornik, B; Kogan, M J; Yutronic, N Gold Nanoparticles Interacting with Beta-Cyclodextrin-Phenylethylamine Inclusion Complex: A Ternary System for Photothermal Drug Release Artículo de revista Acs Applied Materials & Interfaces, 7 (28), pp. 15177-15188, 2015, ISSN: 1944-8244. Resumen | Enlaces | BibTeX | Etiquetas: applications, beta-cyclodextrin, biomedical brain complex, delivery, effect, enhanced gold inclusion laser-ablation, magnetron nanoparticles, permeability, phenylethylamine, photothermal plasmon resonance, retention, silver size, sputtering, surface @article{RN249, title = {Gold Nanoparticles Interacting with Beta-Cyclodextrin-Phenylethylamine Inclusion Complex: A Ternary System for Photothermal Drug Release}, author = { R. Sierpe and E. Lang and P. Jara and A.R. Guerrero and B. Chornik and M.J. Kogan and N. Yutronic}, url = {/brokenurl#<Go to ISI>://WOS:000358558300010}, doi = {10.1021/acsami.5b00186}, issn = {1944-8244}, year = {2015}, date = {2015-01-01}, journal = {Acs Applied Materials & Interfaces}, volume = {7}, number = {28}, pages = {15177-15188}, abstract = {We report the synthesis of a 1:1 beta-cydodextrin-phenylethylamine (beta CD-PhEA) inclusion complex (IC) and the adhesion of gold nanoparticles (AuNPs) onto micro crystals of this complex, which forms a ternary system. The formation of the IC was confirmed by powder X-ray diffraction and NMR analyses (H-1 and ROESY). The stability constant of the IC (760 M-1) was determined using the phase solubility method. The adhesion of AuNPs was obtained using the magnetron sputtering technique, and the presence of AuNPs was confirmed using UV-vis spectroscopy (surface plasmon resonance effect), which showed. an absorbance at 533 nm. The powder X-ray diffractograms of beta CD-PhEA were similar to those of the crystals decorated with AuNPs. A comparison of the one- and two-dimensional NMR spectra of the IC with and without AuNPs suggests partial displacement of the guest to the outside of the beta CD due to attraction toward AuNPs, a characteristic tropism effect. The size, morphology, and distribution of the AuNPs were analyzed using TEM and SEM. The average size of the AuNPs was 14 nm. Changes in the IR and Raman spectra were attributed to the formation of the complex and to the specific interactions of this group with the AuNPs. Laser irradiation assays show that the ternary system beta CD-PhEA-AuNPs in solution enables the release of the guest.}, keywords = {applications, beta-cyclodextrin, biomedical brain complex, delivery, effect, enhanced gold inclusion laser-ablation, magnetron nanoparticles, permeability, phenylethylamine, photothermal plasmon resonance, retention, silver size, sputtering, surface}, pubstate = {published}, tppubtype = {article} } We report the synthesis of a 1:1 beta-cydodextrin-phenylethylamine (beta CD-PhEA) inclusion complex (IC) and the adhesion of gold nanoparticles (AuNPs) onto micro crystals of this complex, which forms a ternary system. The formation of the IC was confirmed by powder X-ray diffraction and NMR analyses (H-1 and ROESY). The stability constant of the IC (760 M-1) was determined using the phase solubility method. The adhesion of AuNPs was obtained using the magnetron sputtering technique, and the presence of AuNPs was confirmed using UV-vis spectroscopy (surface plasmon resonance effect), which showed. an absorbance at 533 nm. The powder X-ray diffractograms of beta CD-PhEA were similar to those of the crystals decorated with AuNPs. A comparison of the one- and two-dimensional NMR spectra of the IC with and without AuNPs suggests partial displacement of the guest to the outside of the beta CD due to attraction toward AuNPs, a characteristic tropism effect. The size, morphology, and distribution of the AuNPs were analyzed using TEM and SEM. The average size of the AuNPs was 14 nm. Changes in the IR and Raman spectra were attributed to the formation of the complex and to the specific interactions of this group with the AuNPs. Laser irradiation assays show that the ternary system beta CD-PhEA-AuNPs in solution enables the release of the guest. |
2017 |
Construction of 6-Thioguanine and 6-Mercaptopurine Carriers Based on Beta Cyclodextrins and Gold Nanoparticles Artículo de revista Carbohydrate Polymers, 177 , pp. 22-31, 2017, ISSN: 0144-8617. |
2015 |
Gold Nanoparticles Interacting with Beta-Cyclodextrin-Phenylethylamine Inclusion Complex: A Ternary System for Photothermal Drug Release Artículo de revista Acs Applied Materials & Interfaces, 7 (28), pp. 15177-15188, 2015, ISSN: 1944-8244. |