Publicaciones 2011-2020

@article{RN115,
title = {Variations in the Chemical Profile and Biological Activities of Licorice (Glycyrrhiza Glabra L.), as Influenced by Harvest Times},
author = { J. Cheel and L. Tumova and C. Areche and P. Van Antwerpen and J. Neve and K. Zouaoui-Boudjeltia and A.S. Martin and I. Vokral and V. Wsol and J. Neugebauerova},
url = {/brokenurl#<Go to ISI>://WOS:000316339400032},
doi = {10.1007/s11738-012-1174-9},
issn = {0137-5881},
year = {2013},
date = {2013-01-01},
journal = {Acta Physiologiae Plantarum},
volume = {35},
number = {4},
pages = {1337-1349},
abstract = {This study investigates the variations in the chemical profile, free radical scavenging, antioxidant and gastroprotective activities of licorice extracts (LE) from plants harvested during the months of February to November. Correlations between biological properties and the chemical composition of LE were also investigated. The results showed that the total contents of phenols, flavonoids and tannins in LE varied at different harvest times. Liquiritin and glycyrrhizin, the major components of LE, varied in the range of 28.65-62.80 and 41.84-114.33 mg g(-1), respectively. The relative proportion of glycyrrhizin derivative (3), glabridin (4), glabrene (5) and liquiritigenin derivative (6), varied in the range of 0.88-11.38 %, 1.86-10.03 %, 1.80-18.40 % and 5.53-16.31 %, respectively. These fluctuations correlated positively with changes in the antioxidant and free radical scavenging activities of licorice. In general, the samples from May and November showed the most favorable free radical scavenging and antioxidant effects, whereas the best gastroprotective effect was in May. Liquiritin and glycyrrhizin, the major constituents in the February and May LE, appeared to contribute to the superoxide radical scavenging and gastroprotective effects. Glabridin and glabrene, the compounds with the highest relative proportion in the November LE, accounted for the antioxidant and DPPH scavenging activities of licorice. It is concluded that the chemical profile of licorice quantitatively varied at different harvest times and these fluctuations determined changes in its bioactivities. These data could pave the way to optimize harvesting protocols for licorice in relation with its health-promoting properties.},
keywords = {activity, antioxidant constituents, extracts, flavonoids, fruits harvest hplc, ldl licorice, liquid-chromatography, myeloperoxidase, oxidation, performance roots, seasonal-variations, times},
pubstate = {published},
tppubtype = {article}
}

@article{RN3_28,
title = {Anti-Proliferative Activity of Meroditerpenoids Isolated from the Brown Alga Stypopodium Flabelliforme against Several Cancer Cell Lines},
author = { D.M. Pereira and J. Cheel and C. Areche and A. San-Martin and J. Rovirosa and L.R. Silva and P. Valentao and P.B. Andrade},
url = {/brokenurl#<Go to ISI>://WOS:000292632500013},
doi = {10.3390/md9050852},
issn = {1660-3397},
year = {2011},
date = {2011-01-01},
journal = {Marine Drugs},
volume = {9},
number = {5},
pages = {852-862},
abstract = {The sea constitutes one of the most promising sources of novel compounds with potential application in human therapeutics. In particular, algae have proved to be an interesting source of new bioactive compounds. In this work, six meroditerpenoids (epitaondiol, epitaondiol diacetate, epitaondiol monoacetate, stypotriol triacetate, 14-ketostypodiol diacetate and stypodiol) isolated from the brown alga Stypopodium flabelliforme were tested for their cell proliferation inhibitory activity in five cell lines. Cell lines tested included human colon adenocarcinoma (Caco-2), human neuroblastoma (SH-SY5Y), rat basophilic leukemia (RBL-2H3), murine macrophages (RAW. 267) and Chinese hamster fibroblasts (V79). Antimicrobial activity of the compounds was also evaluated against Staphylococcus aureus, Salmonella typhimurium, Proteus mirabilis, Bacillus cereus, Enterococcus faecalis and Micrococcus luteus. Overall, the compounds showed good activity against all cell lines, with SH-SY5Y and RAW. 267 being the most susceptible. Antimicrobial capacity was observed for epitaondiol monoacetate, stypotriol triacetate and stypodiol, with the first being the most active. The results suggest that these molecules deserve further studies in order to evaluate their potential as therapeutic agents.},
keywords = {activity, anti-proliferative, antimicrobial antimicrobial, assay epitaondiol, extracts, flabelliforme, marine-algae, meroditerpenoids, natural-products, stypopodium},
pubstate = {published},
tppubtype = {article}
}