Publicaciones 2011-2020

@article{RN3_28,
title = {Anti-Proliferative Activity of Meroditerpenoids Isolated from the Brown Alga Stypopodium Flabelliforme against Several Cancer Cell Lines},
author = { D.M. Pereira and J. Cheel and C. Areche and A. San-Martin and J. Rovirosa and L.R. Silva and P. Valentao and P.B. Andrade},
url = {/brokenurl#<Go to ISI>://WOS:000292632500013},
doi = {10.3390/md9050852},
issn = {1660-3397},
year = {2011},
date = {2011-01-01},
journal = {Marine Drugs},
volume = {9},
number = {5},
pages = {852-862},
abstract = {The sea constitutes one of the most promising sources of novel compounds with potential application in human therapeutics. In particular, algae have proved to be an interesting source of new bioactive compounds. In this work, six meroditerpenoids (epitaondiol, epitaondiol diacetate, epitaondiol monoacetate, stypotriol triacetate, 14-ketostypodiol diacetate and stypodiol) isolated from the brown alga Stypopodium flabelliforme were tested for their cell proliferation inhibitory activity in five cell lines. Cell lines tested included human colon adenocarcinoma (Caco-2), human neuroblastoma (SH-SY5Y), rat basophilic leukemia (RBL-2H3), murine macrophages (RAW. 267) and Chinese hamster fibroblasts (V79). Antimicrobial activity of the compounds was also evaluated against Staphylococcus aureus, Salmonella typhimurium, Proteus mirabilis, Bacillus cereus, Enterococcus faecalis and Micrococcus luteus. Overall, the compounds showed good activity against all cell lines, with SH-SY5Y and RAW. 267 being the most susceptible. Antimicrobial capacity was observed for epitaondiol monoacetate, stypotriol triacetate and stypodiol, with the first being the most active. The results suggest that these molecules deserve further studies in order to evaluate their potential as therapeutic agents.},
keywords = {activity, anti-proliferative, antimicrobial antimicrobial, assay epitaondiol, extracts, flabelliforme, marine-algae, meroditerpenoids, natural-products, stypopodium},
pubstate = {published},
tppubtype = {article}
}

@article{RN22f,
title = {Gastroprotective Activity of Epitaondiol and Sargaol},
author = { C. Areche and A. San-Martin and J. Rovirosa and B. Sepulveda},
url = {/brokenurl#<Go to ISI>://WOS:000294035300005},
doi = {10.1177/1934578X1100600805},
issn = {1934-578x},
year = {2011},
date = {2011-01-01},
journal = {Natural Product Communications},
volume = {6},
number = {8},
pages = {1073-1074},
abstract = {The effects of epitaondiol (1) and sargaol (2), isolated from the brown alga Stypopodium flabelliforme on HCl/ethanol-induced gastric lesions in mice were evaluated and compared with that of lansoprazole. Epitaondiol and sargaol (6.25- 50 mg/kg) dose-dependently inhibited the appearance of gastric lesions in mice, displaying similar values to lansoprazole at 20 mg/kg. Both epitaondiol and sargaol showed gastroprotective activity with ED50 values of 40 mg/kg and 35 mg/kg, respectively. The results suggest that epitaondiol and sargaol protect the gastric mucosa in the HCl/EtOH model in mice.},
keywords = {activity, epitaondiol, flabelliforme gastroprotective sargaol, stypopodium},
pubstate = {published},
tppubtype = {article}
}