Publicaciones 2011-2020

@article{RN238,
title = {Seco-Taondiol, an Unusual Meroterpenoid from the Chilean Seaweed Stypopodium Flabelliforme and Its Gastroprotective Effect in Mouse Model},
author = { C. Areche and J. Benites and A. Cornejo and L.M. Ruiz and O. Garcia-Beltran and M.J. Simirgiotis and B. Sepulveda},
url = {/brokenurl#<Go to ISI>://WOS:000353715900008},
doi = {10.3390/md13041726},
issn = {1660-3397},
year = {2015},
date = {2015-01-01},
journal = {Marine Drugs},
volume = {13},
number = {4},
pages = {1726-1738},
abstract = {Ten known meroterpenoids and the new meroterpenoid 7 were isolated from the Chilean seaweed Stypopodium flabelliforme as their acetylated derivatives. Furthermore, the known metabolite taondiol has been isolated for the first time from this species. The molecular structure of the new metabolite was determined by spectroscopic methods based on 1D- and 2D-NMR. Isolation of 7 represents a keywords step toward a better understanding of the biogenesis of this class of meroterpenoids. Among the meroditerpenoids isolated, stypodiol, isoepitaondiol, epitaondiol and sargaol exhibited gastroprotective activity on the HCl/Ethanol-induced gastric lesions model in mice. Regarding the mode of gastroprotective action, the activity of epitaondiol was reversed significantly when animals were pretreated with indomethacin, N-ethylmaleimide and N-nitro-l-arginine methyl ester (L-NAME) suggesting that prostaglandins, sulfhydryl groups and nitric oxide are involved in their mode of gastroprotective action. In the case of sargaol the gastroprotective activity was attenuated with indomethacin and N-ethylmaleimide, which suggests that prostaglandins and sulfhydryl groups are also involved in the mode of action using this model.},
keywords = {activity, algae, antiproliferative cytoprotection defense, epitaondiol, isoepitaondiol, meroditerpenoids, mucosal natural-products, zonale},
pubstate = {published},
tppubtype = {article}
}

@article{RN3_28,
title = {Anti-Proliferative Activity of Meroditerpenoids Isolated from the Brown Alga Stypopodium Flabelliforme against Several Cancer Cell Lines},
author = { D.M. Pereira and J. Cheel and C. Areche and A. San-Martin and J. Rovirosa and L.R. Silva and P. Valentao and P.B. Andrade},
url = {/brokenurl#<Go to ISI>://WOS:000292632500013},
doi = {10.3390/md9050852},
issn = {1660-3397},
year = {2011},
date = {2011-01-01},
journal = {Marine Drugs},
volume = {9},
number = {5},
pages = {852-862},
abstract = {The sea constitutes one of the most promising sources of novel compounds with potential application in human therapeutics. In particular, algae have proved to be an interesting source of new bioactive compounds. In this work, six meroditerpenoids (epitaondiol, epitaondiol diacetate, epitaondiol monoacetate, stypotriol triacetate, 14-ketostypodiol diacetate and stypodiol) isolated from the brown alga Stypopodium flabelliforme were tested for their cell proliferation inhibitory activity in five cell lines. Cell lines tested included human colon adenocarcinoma (Caco-2), human neuroblastoma (SH-SY5Y), rat basophilic leukemia (RBL-2H3), murine macrophages (RAW. 267) and Chinese hamster fibroblasts (V79). Antimicrobial activity of the compounds was also evaluated against Staphylococcus aureus, Salmonella typhimurium, Proteus mirabilis, Bacillus cereus, Enterococcus faecalis and Micrococcus luteus. Overall, the compounds showed good activity against all cell lines, with SH-SY5Y and RAW. 267 being the most susceptible. Antimicrobial capacity was observed for epitaondiol monoacetate, stypotriol triacetate and stypodiol, with the first being the most active. The results suggest that these molecules deserve further studies in order to evaluate their potential as therapeutic agents.},
keywords = {activity, anti-proliferative, antimicrobial antimicrobial, assay epitaondiol, extracts, flabelliforme, marine-algae, meroditerpenoids, natural-products, stypopodium},
pubstate = {published},
tppubtype = {article}
}