2015 |
Areche, C; Benites, J; Cornejo, A; Ruiz, L M; Garcia-Beltran, O; Simirgiotis, M J; Sepulveda, B Seco-Taondiol, an Unusual Meroterpenoid from the Chilean Seaweed Stypopodium Flabelliforme and Its Gastroprotective Effect in Mouse Model Artículo de revista Marine Drugs, 13 (4), pp. 1726-1738, 2015, ISSN: 1660-3397. Resumen | Enlaces | BibTeX | Etiquetas: activity, algae, antiproliferative cytoprotection defense, epitaondiol, isoepitaondiol, meroditerpenoids, mucosal natural-products, zonale @article{RN238, title = {Seco-Taondiol, an Unusual Meroterpenoid from the Chilean Seaweed Stypopodium Flabelliforme and Its Gastroprotective Effect in Mouse Model}, author = { C. Areche and J. Benites and A. Cornejo and L.M. Ruiz and O. Garcia-Beltran and M.J. Simirgiotis and B. Sepulveda}, url = {/brokenurl#<Go to ISI>://WOS:000353715900008}, doi = {10.3390/md13041726}, issn = {1660-3397}, year = {2015}, date = {2015-01-01}, journal = {Marine Drugs}, volume = {13}, number = {4}, pages = {1726-1738}, abstract = {Ten known meroterpenoids and the new meroterpenoid 7 were isolated from the Chilean seaweed Stypopodium flabelliforme as their acetylated derivatives. Furthermore, the known metabolite taondiol has been isolated for the first time from this species. The molecular structure of the new metabolite was determined by spectroscopic methods based on 1D- and 2D-NMR. Isolation of 7 represents a keywords step toward a better understanding of the biogenesis of this class of meroterpenoids. Among the meroditerpenoids isolated, stypodiol, isoepitaondiol, epitaondiol and sargaol exhibited gastroprotective activity on the HCl/Ethanol-induced gastric lesions model in mice. Regarding the mode of gastroprotective action, the activity of epitaondiol was reversed significantly when animals were pretreated with indomethacin, N-ethylmaleimide and N-nitro-l-arginine methyl ester (L-NAME) suggesting that prostaglandins, sulfhydryl groups and nitric oxide are involved in their mode of gastroprotective action. In the case of sargaol the gastroprotective activity was attenuated with indomethacin and N-ethylmaleimide, which suggests that prostaglandins and sulfhydryl groups are also involved in the mode of action using this model.}, keywords = {activity, algae, antiproliferative cytoprotection defense, epitaondiol, isoepitaondiol, meroditerpenoids, mucosal natural-products, zonale}, pubstate = {published}, tppubtype = {article} } Ten known meroterpenoids and the new meroterpenoid 7 were isolated from the Chilean seaweed Stypopodium flabelliforme as their acetylated derivatives. Furthermore, the known metabolite taondiol has been isolated for the first time from this species. The molecular structure of the new metabolite was determined by spectroscopic methods based on 1D- and 2D-NMR. Isolation of 7 represents a keywords step toward a better understanding of the biogenesis of this class of meroterpenoids. Among the meroditerpenoids isolated, stypodiol, isoepitaondiol, epitaondiol and sargaol exhibited gastroprotective activity on the HCl/Ethanol-induced gastric lesions model in mice. Regarding the mode of gastroprotective action, the activity of epitaondiol was reversed significantly when animals were pretreated with indomethacin, N-ethylmaleimide and N-nitro-l-arginine methyl ester (L-NAME) suggesting that prostaglandins, sulfhydryl groups and nitric oxide are involved in their mode of gastroprotective action. In the case of sargaol the gastroprotective activity was attenuated with indomethacin and N-ethylmaleimide, which suggests that prostaglandins and sulfhydryl groups are also involved in the mode of action using this model. |
2011 |
Areche, C; San-Martin, A; Rovirosa, J; Sepulveda, B Gastroprotective Activity of Epitaondiol and Sargaol Artículo de revista Natural Product Communications, 6 (8), pp. 1073-1074, 2011, ISSN: 1934-578x. Resumen | Enlaces | BibTeX | Etiquetas: activity, epitaondiol, flabelliforme gastroprotective sargaol, stypopodium @article{RN22f, title = {Gastroprotective Activity of Epitaondiol and Sargaol}, author = { C. Areche and A. San-Martin and J. Rovirosa and B. Sepulveda}, url = {/brokenurl#<Go to ISI>://WOS:000294035300005}, doi = {10.1177/1934578X1100600805}, issn = {1934-578x}, year = {2011}, date = {2011-01-01}, journal = {Natural Product Communications}, volume = {6}, number = {8}, pages = {1073-1074}, abstract = {The effects of epitaondiol (1) and sargaol (2), isolated from the brown alga Stypopodium flabelliforme on HCl/ethanol-induced gastric lesions in mice were evaluated and compared with that of lansoprazole. Epitaondiol and sargaol (6.25- 50 mg/kg) dose-dependently inhibited the appearance of gastric lesions in mice, displaying similar values to lansoprazole at 20 mg/kg. Both epitaondiol and sargaol showed gastroprotective activity with ED50 values of 40 mg/kg and 35 mg/kg, respectively. The results suggest that epitaondiol and sargaol protect the gastric mucosa in the HCl/EtOH model in mice.}, keywords = {activity, epitaondiol, flabelliforme gastroprotective sargaol, stypopodium}, pubstate = {published}, tppubtype = {article} } The effects of epitaondiol (1) and sargaol (2), isolated from the brown alga Stypopodium flabelliforme on HCl/ethanol-induced gastric lesions in mice were evaluated and compared with that of lansoprazole. Epitaondiol and sargaol (6.25- 50 mg/kg) dose-dependently inhibited the appearance of gastric lesions in mice, displaying similar values to lansoprazole at 20 mg/kg. Both epitaondiol and sargaol showed gastroprotective activity with ED50 values of 40 mg/kg and 35 mg/kg, respectively. The results suggest that epitaondiol and sargaol protect the gastric mucosa in the HCl/EtOH model in mice. |
2015 |
Seco-Taondiol, an Unusual Meroterpenoid from the Chilean Seaweed Stypopodium Flabelliforme and Its Gastroprotective Effect in Mouse Model Artículo de revista Marine Drugs, 13 (4), pp. 1726-1738, 2015, ISSN: 1660-3397. |
2011 |
Gastroprotective Activity of Epitaondiol and Sargaol Artículo de revista Natural Product Communications, 6 (8), pp. 1073-1074, 2011, ISSN: 1934-578x. |