2015 |
Donoso, V; Bacho, M; Nunez, S; Rovirosa, J; San-Martin, A; Leiva, S Antimicrobial Diterpenes from Azorella Species against Gram-Positive Bacteria Artículo de revista Natural Product Communications, 10 (11), pp. 1915-1916, 2015, ISSN: 1934-578x. Resumen | Enlaces | BibTeX | Etiquetas: acids antibacterial, azorella, carbon compacta, diterpenes, mulinum-crassifolium, mycobacterium-smegmatis, resistant, skeleton, tuberculosis @article{RN233, title = {Antimicrobial Diterpenes from Azorella Species against Gram-Positive Bacteria}, author = { V. Donoso and M. Bacho and S. Nunez and J. Rovirosa and A. San-Martin and S. Leiva}, url = {/brokenurl#<Go to ISI>://WOS:000365932500029}, issn = {1934-578x}, year = {2015}, date = {2015-01-01}, journal = {Natural Product Communications}, volume = {10}, number = {11}, pages = {1915-1916}, abstract = {The present study was aimed at evaluating the antibacterial activity of mulinane and azorellane diterpenes isolated from the Andean plants Azorella compacta and A. trifoliolata and semisynthetic derivatives against reference and multidrug-resistant strains. The results revealed that the semisynthetic compound 7-acetoxy-mulin-9,12-diene (5) exhibited antibacterial activity against reference and multidrug-resistant strains of Staphylococcus aureus and moderate antimycobacterial activity against Mycobacterium smegmatis ATCC 14468.}, keywords = {acids antibacterial, azorella, carbon compacta, diterpenes, mulinum-crassifolium, mycobacterium-smegmatis, resistant, skeleton, tuberculosis}, pubstate = {published}, tppubtype = {article} } The present study was aimed at evaluating the antibacterial activity of mulinane and azorellane diterpenes isolated from the Andean plants Azorella compacta and A. trifoliolata and semisynthetic derivatives against reference and multidrug-resistant strains. The results revealed that the semisynthetic compound 7-acetoxy-mulin-9,12-diene (5) exhibited antibacterial activity against reference and multidrug-resistant strains of Staphylococcus aureus and moderate antimycobacterial activity against Mycobacterium smegmatis ATCC 14468. |
2014 |
studillo-Saavedra, L; Gutierrez, M; Quesada, L; San-Martin, A; Espinoza, L; Penailillo, P New Diterpenes from Azorella Spinosa Artículo de revista Natural Product Communications, 9 (1), pp. 9-12, 2014, ISSN: 1934-578x. Resumen | Enlaces | BibTeX | Etiquetas: azorella, compacta, diterpenes, triterpenoids, umbelliferae @article{RN179, title = {New Diterpenes from Azorella Spinosa}, author = { L. studillo-Saavedra and M. Gutierrez and L. Quesada and A. San-Martin and L. Espinoza and P. Penailillo}, url = {/brokenurl#<Go to ISI>://WOS:000330552200005}, issn = {1934-578x}, year = {2014}, date = {2014-01-01}, journal = {Natural Product Communications}, volume = {9}, number = {1}, pages = {9-12}, abstract = {Two new diterpenes,2-acetoxy-13-hydroxy-mulin-11-ene and 2-acetoxy-mulin-11, 13-diene,have been isolated from the aerial parts of Azorella spinosa and their structures determined by spectroscopic and conventional chemical methods. Furthermore, 2, 13-dihydroxy-mulin-11-ene was obtained using a basic hydrolysis of the first compound. Two diterpenes reported for other Azorella species have also been found, namely mulinolic acid and 13 beta-hydroxyazorellane, as well as the triterpene lactone of ursolic acid,quercetin, and 7-hydroxycoumarin. The compounds were evaluated using antibacterial, antioxidant and enzymatic assays; no significant activity was detected.}, keywords = {azorella, compacta, diterpenes, triterpenoids, umbelliferae}, pubstate = {published}, tppubtype = {article} } Two new diterpenes,2-acetoxy-13-hydroxy-mulin-11-ene and 2-acetoxy-mulin-11, 13-diene,have been isolated from the aerial parts of Azorella spinosa and their structures determined by spectroscopic and conventional chemical methods. Furthermore, 2, 13-dihydroxy-mulin-11-ene was obtained using a basic hydrolysis of the first compound. Two diterpenes reported for other Azorella species have also been found, namely mulinolic acid and 13 beta-hydroxyazorellane, as well as the triterpene lactone of ursolic acid,quercetin, and 7-hydroxycoumarin. The compounds were evaluated using antibacterial, antioxidant and enzymatic assays; no significant activity was detected. |
2015 |
Antimicrobial Diterpenes from Azorella Species against Gram-Positive Bacteria Artículo de revista Natural Product Communications, 10 (11), pp. 1915-1916, 2015, ISSN: 1934-578x. |
2014 |
New Diterpenes from Azorella Spinosa Artículo de revista Natural Product Communications, 9 (1), pp. 9-12, 2014, ISSN: 1934-578x. |