2014 |
studillo-Saavedra, L; Gutierrez, M; Quesada, L; San-Martin, A; Espinoza, L; Penailillo, P New Diterpenes from Azorella Spinosa Artículo de revista Natural Product Communications, 9 (1), pp. 9-12, 2014, ISSN: 1934-578x. Resumen | Enlaces | BibTeX | Etiquetas: azorella, compacta, diterpenes, triterpenoids, umbelliferae @article{RN179, title = {New Diterpenes from Azorella Spinosa}, author = { L. studillo-Saavedra and M. Gutierrez and L. Quesada and A. San-Martin and L. Espinoza and P. Penailillo}, url = {/brokenurl#<Go to ISI>://WOS:000330552200005}, issn = {1934-578x}, year = {2014}, date = {2014-01-01}, journal = {Natural Product Communications}, volume = {9}, number = {1}, pages = {9-12}, abstract = {Two new diterpenes,2-acetoxy-13-hydroxy-mulin-11-ene and 2-acetoxy-mulin-11, 13-diene,have been isolated from the aerial parts of Azorella spinosa and their structures determined by spectroscopic and conventional chemical methods. Furthermore, 2, 13-dihydroxy-mulin-11-ene was obtained using a basic hydrolysis of the first compound. Two diterpenes reported for other Azorella species have also been found, namely mulinolic acid and 13 beta-hydroxyazorellane, as well as the triterpene lactone of ursolic acid,quercetin, and 7-hydroxycoumarin. The compounds were evaluated using antibacterial, antioxidant and enzymatic assays; no significant activity was detected.}, keywords = {azorella, compacta, diterpenes, triterpenoids, umbelliferae}, pubstate = {published}, tppubtype = {article} } Two new diterpenes,2-acetoxy-13-hydroxy-mulin-11-ene and 2-acetoxy-mulin-11, 13-diene,have been isolated from the aerial parts of Azorella spinosa and their structures determined by spectroscopic and conventional chemical methods. Furthermore, 2, 13-dihydroxy-mulin-11-ene was obtained using a basic hydrolysis of the first compound. Two diterpenes reported for other Azorella species have also been found, namely mulinolic acid and 13 beta-hydroxyazorellane, as well as the triterpene lactone of ursolic acid,quercetin, and 7-hydroxycoumarin. The compounds were evaluated using antibacterial, antioxidant and enzymatic assays; no significant activity was detected. |
2011 |
Cassels, B K; Asencio, M Anti-Hiv Activity of Natural Triterpenoids and Hemisynthetic Derivatives 2004-2009 Artículo de revista Phytochemistry Reviews, 10 (4), pp. 545-564, 2011, ISSN: 1568-7767. Resumen | Enlaces | BibTeX | Etiquetas: activity, kadsura-longipedunculata, modification, momordica-charantia, mushroom natural oleanane-type products, protease schisandra-lancifolia, skeleton, structural triterpenes, triterpenoids, unique @article{RN2_40, title = {Anti-Hiv Activity of Natural Triterpenoids and Hemisynthetic Derivatives 2004-2009}, author = { B.K. Cassels and M. Asencio}, url = {/brokenurl#<Go to ISI>://WOS:000297151800007}, doi = {10.1007/s11101-010-9172-2}, issn = {1568-7767}, year = {2011}, date = {2011-01-01}, journal = {Phytochemistry Reviews}, volume = {10}, number = {4}, pages = {545-564}, abstract = {The continued advance of HIV-AIDS makes the development of relatively inexpensive, freely accessible, and mechanistically more diverse antiviral therapies an urgent need. Natural products are, directly or indirectly, an important potential source of compounds meeting these conditions. A review of the recent literature indicates that some hemisynthetic triterpenoid derivatives, particularly belonging to the lupane, oleanane and ursane series, may be nearing a stage where they can be used to complement existing therapeutic approaches. On the other hand, although some natural derivatives of tetracyclic terpenoid families have revealed many novel structures and some promise as anti-HIV substances, their chemical modification to improve their potency and selectivity remains practically untouched. While ongoing work with the more 'classical' pentacyclic triterpenoids will continue to be a fertile field for HIV-AIDS drug discovery, the other structural groups offer unprecedented opportunities for the development of additional substances with useful properties and for the discovery of novel targets for antiviral therapy.}, keywords = {activity, kadsura-longipedunculata, modification, momordica-charantia, mushroom natural oleanane-type products, protease schisandra-lancifolia, skeleton, structural triterpenes, triterpenoids, unique}, pubstate = {published}, tppubtype = {article} } The continued advance of HIV-AIDS makes the development of relatively inexpensive, freely accessible, and mechanistically more diverse antiviral therapies an urgent need. Natural products are, directly or indirectly, an important potential source of compounds meeting these conditions. A review of the recent literature indicates that some hemisynthetic triterpenoid derivatives, particularly belonging to the lupane, oleanane and ursane series, may be nearing a stage where they can be used to complement existing therapeutic approaches. On the other hand, although some natural derivatives of tetracyclic terpenoid families have revealed many novel structures and some promise as anti-HIV substances, their chemical modification to improve their potency and selectivity remains practically untouched. While ongoing work with the more 'classical' pentacyclic triterpenoids will continue to be a fertile field for HIV-AIDS drug discovery, the other structural groups offer unprecedented opportunities for the development of additional substances with useful properties and for the discovery of novel targets for antiviral therapy. |
2014 |
New Diterpenes from Azorella Spinosa Artículo de revista Natural Product Communications, 9 (1), pp. 9-12, 2014, ISSN: 1934-578x. |
2011 |
Anti-Hiv Activity of Natural Triterpenoids and Hemisynthetic Derivatives 2004-2009 Artículo de revista Phytochemistry Reviews, 10 (4), pp. 545-564, 2011, ISSN: 1568-7767. |