Publicaciones 2011-2020

@article{RN284,
title = {Chemical Composition and Antibacterial Activity of Essential Oils from Azorella Spinosa (Apiaceae) against Wild Phytopathogenic Bacteria},
author = { A. Jara-Bermeo and P. Penailillo and A. San-Martin and O. Malagon and G. Gilardoni and M. Gutierrez},
url = {/brokenurl#<Go to ISI>://WOS:000393079900019},
doi = {10.4067/S0717-97072016000400019},
issn = {0717-9707},
year = {2016},
date = {2016-01-01},
journal = {Journal of the Chilean Chemical Society},
volume = {61},
number = {4},
pages = {3246-3249},
abstract = {The aim of the present investigation was to appraise variation in the chemical composition and antimicrobial activity against phytopatogenic bacterial of essential oils from Azorella spinosa. Three samples of A. spinosa were collected in different date in the same area. The essential oils were obtained for hydrodestillation using a Clevenger-type apparatus. The chemical composition of essential oils were analysed using Gas chromatography-mass spectrometry showed variation in the yield and composition, the main detected compounds were monoterpenes such as limonene (10.66-12.30%), tricyclene (10.81-16.99%) and sabinene (9.10-11.49%), the most abundant sesquiterpene was gamma-gurjenene (5.48-8.47%). The biological activity of essential oils from A. spinosa against wild phytopatogenic microorganisms showed selectivity over Pseudomonas syringae. This is the first report of the essential oil composition of A. spinosa, and confirms that natural products obtained from aromatic plants represent an important source of bioactive molecules that could be used as new alternatives for the treatment of phytopatogenic bacteria infections.},
keywords = {activity, antimicrobial antimicrobialactivity, antioxidant, azorella compacta, essential extracts, lamiaceae, oils, plant spinosa, thymus-vulgaris, umbelliferae},
pubstate = {published},
tppubtype = {article}
}

@article{RN179,
title = {New Diterpenes from Azorella Spinosa},
author = { L. studillo-Saavedra and M. Gutierrez and L. Quesada and A. San-Martin and L. Espinoza and P. Penailillo},
url = {/brokenurl#<Go to ISI>://WOS:000330552200005},
issn = {1934-578x},
year = {2014},
date = {2014-01-01},
journal = {Natural Product Communications},
volume = {9},
number = {1},
pages = {9-12},
abstract = {Two new diterpenes,2-acetoxy-13-hydroxy-mulin-11-ene and 2-acetoxy-mulin-11, 13-diene,have been isolated from the aerial parts of Azorella spinosa and their structures determined by spectroscopic and conventional chemical methods. Furthermore, 2, 13-dihydroxy-mulin-11-ene was obtained using a basic hydrolysis of the first compound. Two diterpenes reported for other Azorella species have also been found, namely mulinolic acid and 13 beta-hydroxyazorellane, as well as the triterpene lactone of ursolic acid,quercetin, and 7-hydroxycoumarin. The compounds were evaluated using antibacterial, antioxidant and enzymatic assays; no significant activity was detected.},
keywords = {azorella, compacta, diterpenes, triterpenoids, umbelliferae},
pubstate = {published},
tppubtype = {article}
}

@article{RN185,
title = {A New Mulinane Diterpenoid from the Cushion Shrub Azorella Compacta Growing in Peru},
author = { F. Salgado and C. Areche and B. Sepulveda and M.J. Simirgiotis and F. Caceres and C. Quispe and L. Quispe and T. Cano},
url = {/brokenurl#<Go to ISI>://WOS:000341875000014},
doi = {10.4103/0973-1296.139807},
issn = {0973-1296},
year = {2014},
date = {2014-01-01},
journal = {Pharmacognosy Magazine},
volume = {10},
number = {39},
pages = {543-548},
abstract = {Background: Azorella compacta is a rare yellow-green compact resinous cushion shrub growing from the high Andes of southern Per to northwestern Argentina, and which is a producer of biologically active and unique diterpenoids. Objective: This study investigated the secondary metabolites present in a Peruvian sample of Azorella compacta and the evaluation of gastroprotective activity of the isolated compounds in a gastric-induced ulcer model in mice. Material and Methods: Six secondary metabolites (diterpenoids 1-6) present in the dichloromethane (DCM) extract of A. compacta growing in Per were isolated by a combination of Sephadex LH-20 permeation and silica gel chromatography and their chemical structures were elucidated by spectroscopic methods (NMR) and molecular modeling. The gastroprotective activity of the new compound 1 was evaluated on the HCl/EtOH-induced gastric lesion model in mice and compared to the activity showed by the known compounds. Results: A new mulinane diterpene along with five known diterpenoids have been isolated from a Peruvian sample of A. compacta and the gastroprotective results show that compound 1 is less active than the other known mulinane diterpenoids isolated. Conclusions: A. compacta growing in Per showed the presence of the new mulinane 1, which was poorly active in the HCl/EtOH-induced gastric lesion model in mice. Indeed, the activity was lower than other diterpenoids (2-6) showing an oxygenated function at C-16 or/and C-20, which confirm the role of an oxygenated group (OH or carboxylic acid) for the gastroprotective activity of mulinane compounds.},
keywords = {acids activity, apiaceae, azorella carbon compacta, crassifolium, diterpenoids, gastroprotective madreporica, mulinanes, natural-products, skeleton, umbelliferae},
pubstate = {published},
tppubtype = {article}
}