Publicaciones 2011-2020

@article{RN284,
title = {Chemical Composition and Antibacterial Activity of Essential Oils from Azorella Spinosa (Apiaceae) against Wild Phytopathogenic Bacteria},
author = { A. Jara-Bermeo and P. Penailillo and A. San-Martin and O. Malagon and G. Gilardoni and M. Gutierrez},
url = {/brokenurl#<Go to ISI>://WOS:000393079900019},
doi = {10.4067/S0717-97072016000400019},
issn = {0717-9707},
year = {2016},
date = {2016-01-01},
journal = {Journal of the Chilean Chemical Society},
volume = {61},
number = {4},
pages = {3246-3249},
abstract = {The aim of the present investigation was to appraise variation in the chemical composition and antimicrobial activity against phytopatogenic bacterial of essential oils from Azorella spinosa. Three samples of A. spinosa were collected in different date in the same area. The essential oils were obtained for hydrodestillation using a Clevenger-type apparatus. The chemical composition of essential oils were analysed using Gas chromatography-mass spectrometry showed variation in the yield and composition, the main detected compounds were monoterpenes such as limonene (10.66-12.30%), tricyclene (10.81-16.99%) and sabinene (9.10-11.49%), the most abundant sesquiterpene was gamma-gurjenene (5.48-8.47%). The biological activity of essential oils from A. spinosa against wild phytopatogenic microorganisms showed selectivity over Pseudomonas syringae. This is the first report of the essential oil composition of A. spinosa, and confirms that natural products obtained from aromatic plants represent an important source of bioactive molecules that could be used as new alternatives for the treatment of phytopatogenic bacteria infections.},
keywords = {activity, antimicrobial antimicrobialactivity, antioxidant, azorella compacta, essential extracts, lamiaceae, oils, plant spinosa, thymus-vulgaris, umbelliferae},
pubstate = {published},
tppubtype = {article}
}

@article{RN180,
title = {Diversity of Cultivable Fungi Associated with Antarctic Marine Sponges and Screening for Their Antimicrobial, Antitumoral and Antioxidant Potential},
author = { M. Henriquez and K. Vergara and J. Norambuena and A. Beiza and F. Maza and P. Ubilla and I. Araya and R. Chavez and A. San-Martin and J. Darias and M.J. Darias and I. Vaca},
url = {/brokenurl#<Go to ISI>://WOS:000329248200007},
doi = {10.1007/s11274-013-1418-x},
issn = {0959-3993},
year = {2014},
date = {2014-01-01},
journal = {World Journal of Microbiology & Biotechnology},
volume = {30},
number = {1},
pages = {65-76},
abstract = {The diversity of sponge-associated fungi has been poorly investigated in remote geographical areas like Antarctica. In this study, 101 phenotypically different fungal isolates were obtained from 11 sponge samples collected in King George Island, Antarctica. The analysis of ITS sequences revealed that they belong to the phylum Ascomycota. Sixty-five isolates belong to the genera Geomyces, Penicillium, Epicoccum, Pseudeurotium, Thelebolus, Cladosporium, Aspergillus, Aureobasidium, Phoma, and Trichocladium but 36 isolates could not be identified at genus level. In order to estimate the potential of these isolates as producers of interesting bioactivities, antimicrobial, antitumoral and antioxidant activities of fungal culture extracts were assayed. Around 51 % of the extracts, mainly from the genus Geomyces and non identified relatives, showed antimicrobial activity against some of the bacteria tested. On the other hand, around 42 % of the extracts showed potent antitumoral activity, Geomyces sp. having the best performance. Finally, the potential of the isolated fungi as producers of antioxidant activity seems to be moderate. Our results suggest that fungi associated with Antarctic sponges, particularly Geomyces, would be valuable sources of antimicrobial and antitumoral compounds. To our knowledge, this is the first report describing the biodiversity and the metabolic potential of fungi associated with Antarctic marine sponges.},
keywords = {antarctic antimicrobial, antioxidant, antitumoral, bioactive coastal diversity, fungi, geomyces haliclona-simulans, identification, metabolites, microorganisms natural-products, penicillium, phylogenetic sp., sponges, suberites-zeteki, syndrome, waters, white-nose},
pubstate = {published},
tppubtype = {article}
}

@article{RN114,
title = {Determination of Antibacterial, Antioxidant, Antiplatelet and Inhibition of Cholinesterase Activities from the Methanolic Extracts of Azorella Species (Apiaceae)},
author = { L. Quesada and M. Gutierrez and L. studillo-Saavedra and A. San-Martin and E. Fuentes and I. Palomo and P. Penailillo},
url = {/brokenurl#<Go to ISI>://WOS:000314060700011},
issn = {0717-7917},
year = {2013},
date = {2013-01-01},
journal = {Boletin Latinoamericano Y Del Caribe De Plantas Medicinales Y Aromaticas},
volume = {12},
number = {1},
pages = {99-107},
abstract = {In this study, we investigated the potential antibacterial, antioxidant and anti-platelet activities and the inhibition of cholinesterase from the methanolic extracts obtained from aerial parts of the two species of Azorella: A. spinosa (Constitution, Chile) and A. monantha (Torres del Paine, Enladrillado and Paso Vergara). All extracts showed only moderate inhibitory activity on acetylcholinesterase (AChE), the most active extract with IC50 = 27 mu g/mL was A. spinosa. Inhibition of platelet aggregation induced by ADP presented maximal aggregation to 70 and 57% on extracts of A. spinosa and A. monantha (Paso Vergara), respectively. The most active extract with antioxidant effect was A. spinosa with IC50 of 28.72 mu g/mL. Antibacterial activity of the extract on Escherichia coli, Pseudomonas aeruginosa and Acinetobacter baumannii was not present. The extracts of A. spinosa and A. monantha (Paso Vergara) presented the best results on the activities that were evaluated.},
keywords = {alzheimers-disease, antibacterial, antioxidant, antiplatelet, azorella, cholinesterase, compacta, diterpenoids, phenolics, products, total yareta},
pubstate = {published},
tppubtype = {article}
}

@article{RN100,
title = {Location, Orientation and Dynamics of Two Molecules with Mitochondrial Activity Dissolved in Anionic Lyomesophase. A H-2-Nmr and Md Study},
author = { V.E. Bahamonde-Padilla and M. Martinez-Cifuentes and D. Munoz-Masson and A.I. Ruiz and H. Ahumada and R. Araya-Maturana and J. Soto-Delgado and B. Weiss-Lopez},
url = {/brokenurl#<Go to ISI>://WOS:000309315300021},
doi = {10.4067/S0717-97072012000300021},
issn = {0717-9707},
year = {2012},
date = {2012-01-01},
journal = {Journal of the Chilean Chemical Society},
volume = {57},
number = {3},
pages = {1295-1300},
abstract = {4,4-Dimethyl-5,8-dihydroanthracene-1,9,10(4H)-trione (Q1) and 9,10-Dihydroxy-4,4-dimethyl-5,8-dihydro-1 (4H)-anthracenone (Q2), two molecules that inhibit cancer cell respiration, were selectively deuterated and dissolved in an anionic discotic nematic lyotropic liquid crystal (dnllc) solution. The solution provides a magnetic field oriented anisotropic medium, where the location, average orientation and dynamics of Q(1) and Q(2) were examined by measuring H-2-NMR quadrupole splittings (Delta v(Q)) and H-2 longitudinal relaxation times (T-1). The NMR data shows that both molecules are strongly attached to the aggregate and, when dissolved, increase the alignment of the interface components with the magnetic field. However they present different average orientations. To assist with the interpretation of the experimental results, 300ns Molecular Dynamics (MD) trajectories of a bilayer model of the aggregate were calculated. The results show that both molecules spontaneously diffuse inside the bilayer, to locate in the limit between the hydrophobic core and the interface. The orientations of both molecules in the aggregate are determined by the formation of H-bonds with water.},
keywords = {antioxidant, derivatives, deuterium dipalmitoylphosphatidylcholine, hydration, hydroquinones, longitudinal lyomesophase, parathion, peptides, proteins quadrupole quinones, relaxation respiration, simulations, splitting, time, tumor-cell},
pubstate = {published},
tppubtype = {article}
}