Publicaciones 2011-2020

@article{RN351,
title = {Construction of 6-Thioguanine and 6-Mercaptopurine Carriers Based on Βcyclodextrins and Gold Nanoparticles},
author = { R. Sierpe and M. Noyong and U. Simon and D. Aguayo and J. Huerta and M.J. Kogan and N. Yutronic},
url = {http://www.sciencedirect.com/science/article/pii/S0144861717309785},
doi = {10.1016/j.carbpol.2017.08.102},
issn = {0144-8617},
year = {2017},
date = {2017-01-01},
journal = {Carbohydrate Polymers},
volume = {177},
pages = {22-31},
abstract = {As a novel strategy to overcome some of the therapeutic disadvantages of 6-thioguanine (TG) and 6-mercaptopurine (MP), we propose the inclusion of these drugs in βcyclodextrin (βCD) to form the complexes βCD-TG and βCD-MP, followed by subsequent interaction with gold nanoparticles (AuNPs), generating the ternary systems: βCD-TG-AuNPs and βCD-MP-AuNPs. This modification increased their solubility and improved their stability, betting by a site-specific transport due to their nanometric dimensions, among other advantages. The formation of the complexes was confirmed using powder X-ray diffraction, thermogravimetric analysis and one and two-dimensional NMR. A theoretical study using DFT and molecular modelling was conducted to obtain the more stable tautomeric species of TG and MP in solution and confirm the proposed inclusion geometries. The deposition of AuNPs onto βCD-TG and βCD-MP via sputtering was confirmed by UV\textendashvis spectroscopy. Subsequently, the ternary systems were characterized by TEM, FE-SEM and EDX to directly observe the deposited AuNPs and evaluate their sizes, size dispersion, and composition. Finally, the in vitro permeability of the ternary systems was studied using parallel artificial membrane permeability assay (PAMPA).},
keywords = {Antineoplastic, complexes, delivery dqcauchile, Drug Nanotechnology, sputtering},
pubstate = {published},
tppubtype = {article}
}

@article{RN352,
title = {Construction of 6-Thioguanine and 6-Mercaptopurine Carriers Based on Beta Cyclodextrins and Gold Nanoparticles},
author = { R. Sierpe and M. Noyong and U. Simon and D. Aguayo and J. Huerta and M.J. Kogan and N. Yutronic},
url = {/brokenurl#<Go to ISI>://WOS:000411876200003},
doi = {10.1016/j.carbpol.2017.08.102},
issn = {0144-8617},
year = {2017},
date = {2017-01-01},
journal = {Carbohydrate Polymers},
volume = {177},
pages = {22-31},
abstract = {As a novel strategy to overcome some of the therapeutic disadvantages of 6-thioguanine (TG) and 6-mercaptopurine (MP), we propose the inclusion of these drugs in beta cyclodextrin (beta CD) to form the complexes beta CD-TG and beta CD-MP, followed by subsequent interaction with gold nanoparticles (AuNPs), generating the ternary systems: beta CD-TG-AuNPs and beta CD-MP-AuNPs. This modification increased their solubility and improved their stability, betting by a site-specific transport due to their nanometric dimensions, among other advantages., The formation of the complexes was confirmed using powder X-ray diffraction, thermogravimetric analysis and one and two-dimensional NMR. A theoretical study using DFT and molecular modelling was conducted to obtain the more stable tautomeric species of TG and MP in solution and confirm the proposed inclusion geometries. The deposition of AuNPs onto beta CD-TG and beta CD-MP via sputtering was confirmed by UV-vis spectroscopy. Subsequently, the ternary systems were characterized by TEM, FE-SEM and EDX to directly observe the deposited AuNPs and evaluate their sizes, size dispersion, and composition. Finally, the in vitro permeability of the ternary systems was studied using parallel artificial membrane permeability assay (PAMPA).},
keywords = {anisotropic antineoplastic, applications, cancer, complex, complexes, cytotoxicity delivery, dielectrics, drug drug-delivery, enhanced inclusion ionic-solutions, nanotechnology, permeability, pharmaceutical photothermal solid-state, sputtering, therapy},
pubstate = {published},
tppubtype = {article}
}

@article{RN302,
title = {Molybdenum Trioxide Thin Films Doped with Gold Nanoparticles Grown by a Sequential Methodology: Photochemical Metal-Organic Deposition (Pmod) and Dc-Magnetron Sputtering},
author = { C. Castillo and G. Buono-Core and C. Manzur and N. Yutronic and R. Sierpe and G. Cabello and B. Chornik},
url = {/brokenurl#<Go to ISI>://WOS:000378145500014},
doi = {10.4067/S0717-97072016000100014},
issn = {0717-9707},
year = {2016},
date = {2016-01-01},
journal = {Journal of the Chilean Chemical Society},
volume = {61},
number = {1},
pages = {2816-2820},
abstract = {Gold nanoparticles (AuNPs) were deposited by DC-magnetron sputtering onto molybdenum trioxide (MoO3) thin films grown by Photochemical Metal-Organic Deposition (PMOD) on Si(100) and borosilicate glass substrates. The chemical, optical and morphology properties of the films were studied by UV/Vis Spectroscopy, Scanning Electron Microscopy (SEM), X-Ray Photoelectron Spectroscopy (XPS), and X-Ray Diffraction (XRD). SEM revealed that AuNPs formed after 5 s of sputtering. AuNPs are spherical and have both an average diameter of 18 nm and a relatively narrow size distribution. As the deposition time increases, larger structures are formed by an aggregation of AuNPs. XPS studies of the AuNP/MoO3 films on Si(100) showed the presence of Mo(VI) and Mo(V), which indicated that the films were primarily non-stoichiometric molybdenum oxides. The occurrence of oxygen vacancies in the substrate play an important role to stabilize the AuNPs.},
keywords = {catalysis, diffraction, films, moo3, nanostructures, optical-properties, oxidation, oxide-films, oxides, photoelectron resonance, selective size, spectroscopy, sputtering, support, surface-plasmon temperature, thin x-ray xps},
pubstate = {published},
tppubtype = {article}
}

@article{RN249,
title = {Gold Nanoparticles Interacting with Beta-Cyclodextrin-Phenylethylamine Inclusion Complex: A Ternary System for Photothermal Drug Release},
author = { R. Sierpe and E. Lang and P. Jara and A.R. Guerrero and B. Chornik and M.J. Kogan and N. Yutronic},
url = {/brokenurl#<Go to ISI>://WOS:000358558300010},
doi = {10.1021/acsami.5b00186},
issn = {1944-8244},
year = {2015},
date = {2015-01-01},
journal = {Acs Applied Materials & Interfaces},
volume = {7},
number = {28},
pages = {15177-15188},
abstract = {We report the synthesis of a 1:1 beta-cydodextrin-phenylethylamine (beta CD-PhEA) inclusion complex (IC) and the adhesion of gold nanoparticles (AuNPs) onto micro crystals of this complex, which forms a ternary system. The formation of the IC was confirmed by powder X-ray diffraction and NMR analyses (H-1 and ROESY). The stability constant of the IC (760 M-1) was determined using the phase solubility method. The adhesion of AuNPs was obtained using the magnetron sputtering technique, and the presence of AuNPs was confirmed using UV-vis spectroscopy (surface plasmon resonance effect), which showed. an absorbance at 533 nm. The powder X-ray diffractograms of beta CD-PhEA were similar to those of the crystals decorated with AuNPs. A comparison of the one- and two-dimensional NMR spectra of the IC with and without AuNPs suggests partial displacement of the guest to the outside of the beta CD due to attraction toward AuNPs, a characteristic tropism effect. The size, morphology, and distribution of the AuNPs were analyzed using TEM and SEM. The average size of the AuNPs was 14 nm. Changes in the IR and Raman spectra were attributed to the formation of the complex and to the specific interactions of this group with the AuNPs. Laser irradiation assays show that the ternary system beta CD-PhEA-AuNPs in solution enables the release of the guest.},
keywords = {applications, beta-cyclodextrin, biomedical brain complex, delivery, effect, enhanced gold inclusion laser-ablation, magnetron nanoparticles, permeability, phenylethylamine, photothermal plasmon resonance, retention, silver size, sputtering, surface},
pubstate = {published},
tppubtype = {article}
}

@article{RN199,
title = {Gamma-Cyclodextrin/Alkylthiol Inclusion Compounds Crystals as Substrates for the Formation and Immobilization of Gold Nanoparticles Produced by Magnetron Sputtering},
author = { M. Diaz and N. Silva and N. Yutronic and E. Pena and B. Chornik and P. Jara},
url = {/brokenurl#<Go to ISI>://WOS:000341814600017},
doi = {10.1007/s10847-014-0417-3},
issn = {1388-3127},
year = {2014},
date = {2014-01-01},
journal = {Journal of Inclusion Phenomena and Macrocyclic Chemistry},
volume = {80},
number = {1-2},
pages = {133-138},
abstract = {In this work, we report the nanodecoration of microcrystals of inclusion compound (IC) of gamma-cyclodextrin (gamma-CD) that contain octanethiol, decanethiol and dodecanethiol. Crystals of these ICs provide a suitable environment for nucleation, growth and immobilization of gold nanoparticles that were obtained by the magnetron sputtering technique. The use of gamma-CD IC substrates with a specific surface morphology (i.e., the functional group of the guest molecule faces outward preferentially from a crystal plane) is an efficient method for the preparation of AuNPs with low size dispersion, which is due to the high affinity between the functional group of the surfactant alkylthiol guest with the metal nanoparticles.},
keywords = {complexes compounds, cyclodextrin, gold inclusion magnetron nanoparticles, sputtering, stability},
pubstate = {published},
tppubtype = {article}
}

@article{RN81,
title = {Ordered Arrangements of Metal Nanoparticles on Alpha-Cyclodextrin Inclusion Complexes by Magnetron Sputtering},
author = { L. Barrientos-Poblete and P. Allende-Gonz\'{a}lez and C. Orellana and P. Jara},
url = {/brokenurl#<Go to ISI>://WOS:000300180100050},
doi = {10.1016/j.ica.2011.10.032},
issn = {0020-1693},
year = {2012},
date = {2012-01-01},
journal = {Inorganica Chimica Acta},
volume = {380},
pages = {372-377},
publisher = {2011 Elsevier B.V.},
abstract = {An ordered self-assembly of copper, silver and gold nanoparticles onto crystal faces of alpha-cyclodextrin/1-octanethiol and 2 alpha-cyclodextrin/1-octylamine inclusion complexes by means of physical vapor deposition (magnetron sputtering) has been achieved. The preferential deposition on the (001) plane of the supramolecular crystal occurs because the -SH and -NH2 groups from the guest molecules found within the alpha-cyclodextrin protrude into that plane. These functional groups form a two-dimensional hexagonal lattice that interacts with the metal nanoparticles, arranging them in an ordered way.},
keywords = {catalysis, colloids, gold guest host interaction, magnetron metal metal-guest molecules, monolayer, nanoparticles, nanostructures, particles, size, sputtering, stabilization, supramolecular surface},
pubstate = {published},
tppubtype = {article}
}